Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography

Seong Hwan Kim, Eung Ju Kim, Min Kyu Kim, In Sang Yun, Woo Jung Park, Sang Jin Han, Goo Yeong Cho, Young Jin Choi, Kyung Soon Hong, Kyoo Rok Han, Dong Jin Oh, Chong Yun Rhim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Objectives: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. Subjects and Methods: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. Results: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8 ± 11.8/8.4 ± 8.0 and 20.5 ± 13.6/6.7 ± 6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p = 0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p < 0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p < 0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p = 0.709). Conclusion: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalKorean Circulation Journal
Volume36
Issue number2
Publication statusPublished - 2006 Feb 1
Externally publishedYes

Fingerprint

Nicorandil
Radial Artery
Spasm
Coronary Angiography
Vasodilation
Blood Pressure
Parasympatholytics
Oximetry
Catheterization
Pathologic Constriction

Keywords

  • Coronary angiography
  • Nicorandil
  • Radial artery
  • Spasm

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography. / Kim, Seong Hwan; Kim, Eung Ju; Kim, Min Kyu; Yun, In Sang; Park, Woo Jung; Han, Sang Jin; Cho, Goo Yeong; Choi, Young Jin; Hong, Kyung Soon; Han, Kyoo Rok; Oh, Dong Jin; Rhim, Chong Yun.

In: Korean Circulation Journal, Vol. 36, No. 2, 01.02.2006, p. 133-139.

Research output: Contribution to journalArticle

Kim, SH, Kim, EJ, Kim, MK, Yun, IS, Park, WJ, Han, SJ, Cho, GY, Choi, YJ, Hong, KS, Han, KR, Oh, DJ & Rhim, CY 2006, 'Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography', Korean Circulation Journal, vol. 36, no. 2, pp. 133-139.
Kim, Seong Hwan ; Kim, Eung Ju ; Kim, Min Kyu ; Yun, In Sang ; Park, Woo Jung ; Han, Sang Jin ; Cho, Goo Yeong ; Choi, Young Jin ; Hong, Kyung Soon ; Han, Kyoo Rok ; Oh, Dong Jin ; Rhim, Chong Yun. / Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography. In: Korean Circulation Journal. 2006 ; Vol. 36, No. 2. pp. 133-139.
@article{04686ceee7fd4238aa2fafddc60c4623,
title = "Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography",
abstract = "Background and Objectives: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. Subjects and Methods: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. Results: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8 ± 11.8/8.4 ± 8.0 and 20.5 ± 13.6/6.7 ± 6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p = 0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p < 0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p < 0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58{\%} in nicorandil and cocktail groups, respectively, p = 0.709). Conclusion: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.",
keywords = "Coronary angiography, Nicorandil, Radial artery, Spasm",
author = "Kim, {Seong Hwan} and Kim, {Eung Ju} and Kim, {Min Kyu} and Yun, {In Sang} and Park, {Woo Jung} and Han, {Sang Jin} and Cho, {Goo Yeong} and Choi, {Young Jin} and Hong, {Kyung Soon} and Han, {Kyoo Rok} and Oh, {Dong Jin} and Rhim, {Chong Yun}",
year = "2006",
month = "2",
day = "1",
language = "English",
volume = "36",
pages = "133--139",
journal = "Korean Circulation Journal",
issn = "1738-5520",
publisher = "Korean Society of Circulation",
number = "2",

}

TY - JOUR

T1 - Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography

AU - Kim, Seong Hwan

AU - Kim, Eung Ju

AU - Kim, Min Kyu

AU - Yun, In Sang

AU - Park, Woo Jung

AU - Han, Sang Jin

AU - Cho, Goo Yeong

AU - Choi, Young Jin

AU - Hong, Kyung Soon

AU - Han, Kyoo Rok

AU - Oh, Dong Jin

AU - Rhim, Chong Yun

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Background and Objectives: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. Subjects and Methods: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. Results: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8 ± 11.8/8.4 ± 8.0 and 20.5 ± 13.6/6.7 ± 6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p = 0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p < 0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p < 0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p = 0.709). Conclusion: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.

AB - Background and Objectives: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. Subjects and Methods: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. Results: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8 ± 11.8/8.4 ± 8.0 and 20.5 ± 13.6/6.7 ± 6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p = 0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p < 0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p < 0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p = 0.709). Conclusion: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.

KW - Coronary angiography

KW - Nicorandil

KW - Radial artery

KW - Spasm

UR - http://www.scopus.com/inward/record.url?scp=33646470071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646470071&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33646470071

VL - 36

SP - 133

EP - 139

JO - Korean Circulation Journal

JF - Korean Circulation Journal

SN - 1738-5520

IS - 2

ER -