Comparison of the major clinical outcomes for the use of endeavor® and resolute integrity® zotarolimus-eluting stents during a three-year follow-up

Yong Hoon Kim, Ae Young Her, Seung Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim, Cheol Ung Choi, Chang Gyu Park, Hong Seog Seo

    Research output: Contribution to journalArticlepeer-review


    Background: Endeavor®-zotarolimus-eluting stent (E-ZES) was the first ZES to be developed, and Resolute integrity®-ZES (I-ZES) has been developed more recently. Comparative studies on long-term usage of these two ZESs have been rare. Objectives: The aim of this study was to compare the efficacy and safety of E-ZES and I-ZES during a long-term follow-up of patients who underwent percutaneous coronary intervention (PCI). Methods: A total of 767 patients who underwent PCI with E-ZES or I-ZES were eligible for this study. The primary endpoint was the occurrence of major adverse cardiac events (MACEs), defined as the composite of all-cause death, non-fatal myocardial infarction (MI), and any repeat revascularization. The secondary endpoint was stent thrombosis (ST). Results: After propensity score-matched (PSM) analysis, two PSM groups (193 pairs, n = 386, C-statistic = 0.824) were generated. During the 3-year follow-up period, the cumulative incidence of MACEs (hazard ratio [HR], 0.837; 95% confidence interval [CI], 0.464-1.508; p = 0.553) and ST (HR, 0.398; 95% CI, 0.077-2.052; p = 0.271) was similar for the E-ZES and I-ZES groups. Additionally, the cumulative incidences of all-cause death, cardiac death, non-fatal MI, and any repeat revascularization were not significantly different between the two groups. Conclusions: Although I-ZES utilizes a more advanced stent platform, stent design, and polymer system than E-ZES, both the ZESs showed comparable efficacy and safety during the 3-year follow-up period in this single-center, all-comers registry. However, further large-scaled, randomized, well-controlled trials with long-term follow-up are needed to verify these results.

    Original languageEnglish
    Article number4
    JournalGlobal heart
    Issue number1
    Publication statusPublished - 2020 Feb 6


    • Clinical outcomes
    • Drug-eluting stent
    • Zotarolimus

    ASJC Scopus subject areas

    • Epidemiology
    • Community and Home Care
    • Cardiology and Cardiovascular Medicine


    Dive into the research topics of 'Comparison of the major clinical outcomes for the use of endeavor<sup>®</sup> and resolute integrity<sup>®</sup> zotarolimus-eluting stents during a three-year follow-up'. Together they form a unique fingerprint.

    Cite this