Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02)

Ji Yun Lee, Jong Mu Sun, Dong Ryul Oh, Sung Hee Lim, Juna Goo, Se Hoon Lee, Sung Bae Kim, Keon Uk Park, Hoon Kyo Kim, Dae Sik Hong, Jun Suk Kim, Seong Geun Kim, Seong Yoon Yi, Hwan Jung Yun, Myung Soo Hyun, Hyo Jung Kim, Sin Ho Jung, Keunchil Park, Yong Chan Ahn, Myung Ju Ahn

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15 Citations (Scopus)

Abstract

Purpose Triweekly delivery of cisplatin concurrent with a course of radiation therapy (RT) has been the standard regimen for treatment of locally advanced nasopharyngeal carcinoma (NPC) despite a high level of concern regarding treatment-related complications. We conducted a randomized phase II study to compare weekly and triweekly cisplatin delivery during RT with respect to efficacy and toxicity profiles. Material and methods Patients with locally advanced NPC (stage II-IVb) were randomly assigned to a regimen of either seven doses of cisplatin (40 mg/m2) given once a week or three doses of cisplatin (100 mg/m2) given every 3 weeks concurrently during RT. Results Of 109 eligible patients, 53 were assigned to the weekly regimen and 56 to the triweekly regimen. The two groups were comparable with respect to demographic and clinical characteristics. There were no significant differences in mean RT dose (68.3 Gy vs. 67.3 Gy, p = 0.559) and mean cisplatin dose (248.9 mg/m2 vs. 256.6 mg/m2, p = 0.433) between the two regimens. The primary endpoint was 3-year progression-free survival, which was not different between the regimens (64.9% vs. 63.8%, p = 0.074). Overall, the occurrence of grade 3-4 toxicities was similar between the two arms (47.2% vs. 39.3%, p = 0.443). Quality of life (QoL) related to functional outcomes 3 weeks after treatment completion was better for the weekly regimen. Conclusions Although no definitive conclusions can be made, a once-weekly cisplatin regimen appears to be associated with improved QoL and is not inferior to the standard triweekly regimen with respect to efficacy and toxicity profiles.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalRadiotherapy and Oncology
Volume118
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Keywords

  • Concurrent chemoradiation therapy
  • Efficacy
  • Nasopharyngeal cancer
  • Quality of life
  • Toxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Lee, J. Y., Sun, J. M., Oh, D. R., Lim, S. H., Goo, J., Lee, S. H., Kim, S. B., Park, K. U., Kim, H. K., Hong, D. S., Kim, J. S., Kim, S. G., Yi, S. Y., Yun, H. J., Hyun, M. S., Kim, H. J., Jung, S. H., Park, K., Ahn, Y. C., & Ahn, M. J. (2016). Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02). Radiotherapy and Oncology, 118(2), 244-250. https://doi.org/10.1016/j.radonc.2015.11.030