Comparison on the efficacy of disinfectants used in automated endoscope reprocessors: PHMB-DBAC versus orthophthalaldehyde

Sun Young Kim, Hong Sik Lee, Jong Jin Hyun, Min Ho Seo, Sun Young Yim, Ha Young Oh, Hye Sook Kim, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hoon-Jai Chun, Soon-Ho Um, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical). Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified. Results: The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA. Conclusions: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalClinical Endoscopy
Volume44
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Benzalkonium Compounds
Disinfectants
Endoscopes
Disinfection
Staphylococcus hominis
Pseudomonas putida
Korea
Agar
Confidence Intervals
Safety

Keywords

  • Disinfectants
  • Endoscope reprocessing
  • High-level disinfection

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Comparison on the efficacy of disinfectants used in automated endoscope reprocessors : PHMB-DBAC versus orthophthalaldehyde. / Kim, Sun Young; Lee, Hong Sik; Hyun, Jong Jin; Seo, Min Ho; Yim, Sun Young; Oh, Ha Young; Kim, Hye Sook; Keum, Bora; Seo, Yeon Seok; Kim, Yong Sik; Jeen, Yoon Tae; Chun, Hoon-Jai; Um, Soon-Ho; Kim, Chang Duck; Ryu, Ho Sang.

In: Clinical Endoscopy, Vol. 44, No. 2, 01.12.2011, p. 109-115.

Research output: Contribution to journalArticle

Kim, Sun Young ; Lee, Hong Sik ; Hyun, Jong Jin ; Seo, Min Ho ; Yim, Sun Young ; Oh, Ha Young ; Kim, Hye Sook ; Keum, Bora ; Seo, Yeon Seok ; Kim, Yong Sik ; Jeen, Yoon Tae ; Chun, Hoon-Jai ; Um, Soon-Ho ; Kim, Chang Duck ; Ryu, Ho Sang. / Comparison on the efficacy of disinfectants used in automated endoscope reprocessors : PHMB-DBAC versus orthophthalaldehyde. In: Clinical Endoscopy. 2011 ; Vol. 44, No. 2. pp. 109-115.
@article{5e373ec21e404543bdb07a76e3c37984,
title = "Comparison on the efficacy of disinfectants used in automated endoscope reprocessors: PHMB-DBAC versus orthophthalaldehyde",
abstract = "Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical). Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified. Results: The culture-positive rate at the endoscope tip and working channel was 0{\%} and 2.33{\%} for COOLENDO/PHMB-DBAC and 4.65{\%} and 0{\%} for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA. Conclusions: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.",
keywords = "Disinfectants, Endoscope reprocessing, High-level disinfection",
author = "Kim, {Sun Young} and Lee, {Hong Sik} and Hyun, {Jong Jin} and Seo, {Min Ho} and Yim, {Sun Young} and Oh, {Ha Young} and Kim, {Hye Sook} and Bora Keum and Seo, {Yeon Seok} and Kim, {Yong Sik} and Jeen, {Yoon Tae} and Hoon-Jai Chun and Soon-Ho Um and Kim, {Chang Duck} and Ryu, {Ho Sang}",
year = "2011",
month = "12",
day = "1",
doi = "10.5946/ce.2011.44.2.109",
language = "English",
volume = "44",
pages = "109--115",
journal = "Clinical Endoscopy",
issn = "2234-2400",
publisher = "Korean Society of Gastrointestinal Endoscopy",
number = "2",

}

TY - JOUR

T1 - Comparison on the efficacy of disinfectants used in automated endoscope reprocessors

T2 - PHMB-DBAC versus orthophthalaldehyde

AU - Kim, Sun Young

AU - Lee, Hong Sik

AU - Hyun, Jong Jin

AU - Seo, Min Ho

AU - Yim, Sun Young

AU - Oh, Ha Young

AU - Kim, Hye Sook

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Kim, Yong Sik

AU - Jeen, Yoon Tae

AU - Chun, Hoon-Jai

AU - Um, Soon-Ho

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical). Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified. Results: The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA. Conclusions: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.

AB - Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical). Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified. Results: The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA. Conclusions: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.

KW - Disinfectants

KW - Endoscope reprocessing

KW - High-level disinfection

UR - http://www.scopus.com/inward/record.url?scp=84876408988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876408988&partnerID=8YFLogxK

U2 - 10.5946/ce.2011.44.2.109

DO - 10.5946/ce.2011.44.2.109

M3 - Article

C2 - 22741121

AN - SCOPUS:84876408988

VL - 44

SP - 109

EP - 115

JO - Clinical Endoscopy

JF - Clinical Endoscopy

SN - 2234-2400

IS - 2

ER -