Comparisons of prognostic scoring systems for myelodysplastic syndromes

A Korean multicenter study

J. J. Lee, H. J. Kim, I. J. Chung, J. S. Kim, S. K. Sohn, Byung Soo Kim, K. H. Lee, J. Y. Kwak, Y. H. Park, J. S. Ahn, Y. S. Park

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have conducted a multicenter collaborative retrospective analysis to evaluate clinical characteristics and to compare prognostic scoring systems of 149 Korean patients with myelodysplastic syndromes (MDS). The median age of the patients was 53 years (range 17-82 years) with high of the patients being younger than 40 years. Median survival was 22.6 months, and 25 patients (17%) progressed to acute myelogenous leukemia (AML) with a median interval of 6 months (range 1-45 months). Major independent variables assessed by multivariate analysis were FAB subtypes and bone marrow (BM) blast percentages for survival and BM blast percentages for AML transformation. To compare the various scoring systems in the prediction for survival and transformation to AML, FAB, Sanz and Bournemouth scoring systems were applied to all patients, while the international prognostic scoring system (IPSS), Lille and Toyarea scoring systems were applied to 91 patients. The Sanz scoring system (P < 0.0001), FAB classification (P < 0.0001), IPSS (P < 0.001), and Toyama scoring system (P < 0.005) were highly predictive for survival showed greater discrimination than that of the other systems. For AML transformation, the IPSS (P < 0.0001), Toyama scoring system (P < 0.0001), FAB classification (P < 0.0001), and Lille scoring system (P < 0.005) successfully discriminated risk groups. Although the prognostic factors and the distribution of age were different from those in Western reports, the IPSS and Toyama scoring system were applicable for predicting survival and leukemic transformation in Korean patients with MDS.

Original languageEnglish
Pages (from-to)425-432
Number of pages8
JournalLeukemia Research
Volume23
Issue number5
DOIs
Publication statusPublished - 1999 May 1

Fingerprint

Myelodysplastic Syndromes
Multicenter Studies
Acute Myeloid Leukemia
Survival
Bone Marrow
Age Distribution
Multivariate Analysis

Keywords

  • Korean
  • Leukemic transformation
  • Myelodysplastic syndromes
  • Prognostic factors
  • Scoring system

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Comparisons of prognostic scoring systems for myelodysplastic syndromes : A Korean multicenter study. / Lee, J. J.; Kim, H. J.; Chung, I. J.; Kim, J. S.; Sohn, S. K.; Kim, Byung Soo; Lee, K. H.; Kwak, J. Y.; Park, Y. H.; Ahn, J. S.; Park, Y. S.

In: Leukemia Research, Vol. 23, No. 5, 01.05.1999, p. 425-432.

Research output: Contribution to journalArticle

Lee, JJ, Kim, HJ, Chung, IJ, Kim, JS, Sohn, SK, Kim, BS, Lee, KH, Kwak, JY, Park, YH, Ahn, JS & Park, YS 1999, 'Comparisons of prognostic scoring systems for myelodysplastic syndromes: A Korean multicenter study', Leukemia Research, vol. 23, no. 5, pp. 425-432. https://doi.org/10.1016/S0145-2126(99)00032-6
Lee, J. J. ; Kim, H. J. ; Chung, I. J. ; Kim, J. S. ; Sohn, S. K. ; Kim, Byung Soo ; Lee, K. H. ; Kwak, J. Y. ; Park, Y. H. ; Ahn, J. S. ; Park, Y. S. / Comparisons of prognostic scoring systems for myelodysplastic syndromes : A Korean multicenter study. In: Leukemia Research. 1999 ; Vol. 23, No. 5. pp. 425-432.
@article{c056dc0d6bf64168b5801d14572ee32b,
title = "Comparisons of prognostic scoring systems for myelodysplastic syndromes: A Korean multicenter study",
abstract = "We have conducted a multicenter collaborative retrospective analysis to evaluate clinical characteristics and to compare prognostic scoring systems of 149 Korean patients with myelodysplastic syndromes (MDS). The median age of the patients was 53 years (range 17-82 years) with high of the patients being younger than 40 years. Median survival was 22.6 months, and 25 patients (17{\%}) progressed to acute myelogenous leukemia (AML) with a median interval of 6 months (range 1-45 months). Major independent variables assessed by multivariate analysis were FAB subtypes and bone marrow (BM) blast percentages for survival and BM blast percentages for AML transformation. To compare the various scoring systems in the prediction for survival and transformation to AML, FAB, Sanz and Bournemouth scoring systems were applied to all patients, while the international prognostic scoring system (IPSS), Lille and Toyarea scoring systems were applied to 91 patients. The Sanz scoring system (P < 0.0001), FAB classification (P < 0.0001), IPSS (P < 0.001), and Toyama scoring system (P < 0.005) were highly predictive for survival showed greater discrimination than that of the other systems. For AML transformation, the IPSS (P < 0.0001), Toyama scoring system (P < 0.0001), FAB classification (P < 0.0001), and Lille scoring system (P < 0.005) successfully discriminated risk groups. Although the prognostic factors and the distribution of age were different from those in Western reports, the IPSS and Toyama scoring system were applicable for predicting survival and leukemic transformation in Korean patients with MDS.",
keywords = "Korean, Leukemic transformation, Myelodysplastic syndromes, Prognostic factors, Scoring system",
author = "Lee, {J. J.} and Kim, {H. J.} and Chung, {I. J.} and Kim, {J. S.} and Sohn, {S. K.} and Kim, {Byung Soo} and Lee, {K. H.} and Kwak, {J. Y.} and Park, {Y. H.} and Ahn, {J. S.} and Park, {Y. S.}",
year = "1999",
month = "5",
day = "1",
doi = "10.1016/S0145-2126(99)00032-6",
language = "English",
volume = "23",
pages = "425--432",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Comparisons of prognostic scoring systems for myelodysplastic syndromes

T2 - A Korean multicenter study

AU - Lee, J. J.

AU - Kim, H. J.

AU - Chung, I. J.

AU - Kim, J. S.

AU - Sohn, S. K.

AU - Kim, Byung Soo

AU - Lee, K. H.

AU - Kwak, J. Y.

AU - Park, Y. H.

AU - Ahn, J. S.

AU - Park, Y. S.

PY - 1999/5/1

Y1 - 1999/5/1

N2 - We have conducted a multicenter collaborative retrospective analysis to evaluate clinical characteristics and to compare prognostic scoring systems of 149 Korean patients with myelodysplastic syndromes (MDS). The median age of the patients was 53 years (range 17-82 years) with high of the patients being younger than 40 years. Median survival was 22.6 months, and 25 patients (17%) progressed to acute myelogenous leukemia (AML) with a median interval of 6 months (range 1-45 months). Major independent variables assessed by multivariate analysis were FAB subtypes and bone marrow (BM) blast percentages for survival and BM blast percentages for AML transformation. To compare the various scoring systems in the prediction for survival and transformation to AML, FAB, Sanz and Bournemouth scoring systems were applied to all patients, while the international prognostic scoring system (IPSS), Lille and Toyarea scoring systems were applied to 91 patients. The Sanz scoring system (P < 0.0001), FAB classification (P < 0.0001), IPSS (P < 0.001), and Toyama scoring system (P < 0.005) were highly predictive for survival showed greater discrimination than that of the other systems. For AML transformation, the IPSS (P < 0.0001), Toyama scoring system (P < 0.0001), FAB classification (P < 0.0001), and Lille scoring system (P < 0.005) successfully discriminated risk groups. Although the prognostic factors and the distribution of age were different from those in Western reports, the IPSS and Toyama scoring system were applicable for predicting survival and leukemic transformation in Korean patients with MDS.

AB - We have conducted a multicenter collaborative retrospective analysis to evaluate clinical characteristics and to compare prognostic scoring systems of 149 Korean patients with myelodysplastic syndromes (MDS). The median age of the patients was 53 years (range 17-82 years) with high of the patients being younger than 40 years. Median survival was 22.6 months, and 25 patients (17%) progressed to acute myelogenous leukemia (AML) with a median interval of 6 months (range 1-45 months). Major independent variables assessed by multivariate analysis were FAB subtypes and bone marrow (BM) blast percentages for survival and BM blast percentages for AML transformation. To compare the various scoring systems in the prediction for survival and transformation to AML, FAB, Sanz and Bournemouth scoring systems were applied to all patients, while the international prognostic scoring system (IPSS), Lille and Toyarea scoring systems were applied to 91 patients. The Sanz scoring system (P < 0.0001), FAB classification (P < 0.0001), IPSS (P < 0.001), and Toyama scoring system (P < 0.005) were highly predictive for survival showed greater discrimination than that of the other systems. For AML transformation, the IPSS (P < 0.0001), Toyama scoring system (P < 0.0001), FAB classification (P < 0.0001), and Lille scoring system (P < 0.005) successfully discriminated risk groups. Although the prognostic factors and the distribution of age were different from those in Western reports, the IPSS and Toyama scoring system were applicable for predicting survival and leukemic transformation in Korean patients with MDS.

KW - Korean

KW - Leukemic transformation

KW - Myelodysplastic syndromes

KW - Prognostic factors

KW - Scoring system

UR - http://www.scopus.com/inward/record.url?scp=0032902494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032902494&partnerID=8YFLogxK

U2 - 10.1016/S0145-2126(99)00032-6

DO - 10.1016/S0145-2126(99)00032-6

M3 - Article

VL - 23

SP - 425

EP - 432

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 5

ER -