Compensatory renal growth due to neonatal ureteral obstruction: Implications for clinical studies

Kee Hwan Yoo, Barbara A. Thornhill, Michael S. Forbes, Robert L. Chevalier

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In response to unilateral ureteral obstruction (UUO), the contralateral kidney undergoes compensatory renal growth, which is enhanced in early development. We investigated the renal growth response to UUO in the neonatal rat. Within 2 days of birth, animals were subjected to sham-operation, complete UUO, or variable partial UUO, and kidneys were harvested 3-60 days later. Contralateral kidney weight increased after only 7 days of complete UUO. Increase in contralateral kidney weight was not significant for partial UUO until 45 days, but kidney/body weight ratio increased after only 14 days of 0.3 mm partial UUO. The rate of contralateral renal growth increased with age and with increasing severity of UUO. In rats subjected to 45 days UUO, glomerular area was proportional to kidney/body weight ratio (r=0.61, p<0.01). We conclude that the rate of compensatory renal growth is dependent on the severity and duration of obstruction, and takes place at the single nephron level. The results suggest that biologic variability limits the early detection of compensatory renal growth, which is compounded by limitations in measuring renal size by clinical imaging. Factoring kidney length (or volume) by intervertebral length (or body surface area) should improve the precision of tracking renal growth.

Original languageEnglish
Pages (from-to)368-375
Number of pages8
JournalPediatric Nephrology
Volume21
Issue number3
DOIs
Publication statusPublished - 2006 Mar 1

Fingerprint

Ureteral Obstruction
Kidney
Growth
Clinical Studies
Body Weight
Weights and Measures
Body Surface Area
Nephrons

Keywords

  • Hydronephrosis
  • Hypertrophy
  • Neonate
  • Rat
  • Renal development

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Compensatory renal growth due to neonatal ureteral obstruction : Implications for clinical studies. / Yoo, Kee Hwan; Thornhill, Barbara A.; Forbes, Michael S.; Chevalier, Robert L.

In: Pediatric Nephrology, Vol. 21, No. 3, 01.03.2006, p. 368-375.

Research output: Contribution to journalArticle

Yoo, Kee Hwan ; Thornhill, Barbara A. ; Forbes, Michael S. ; Chevalier, Robert L. / Compensatory renal growth due to neonatal ureteral obstruction : Implications for clinical studies. In: Pediatric Nephrology. 2006 ; Vol. 21, No. 3. pp. 368-375.
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