Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolated from Mongolian patients with chronic HBV infection

Zagaa Odgerel, In Keun Choi, Kwan Soo Byun, Chin Yong Pak, Shannon Bennett, Se Hun Gu, KwangSook Park, Sun-Ho Kee, Ki-Joon Song, Jin Won Song

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although there is a report of a high rate of hepatitis B virus (HBV) infection in Mongolia, the entire nucleotide sequence of HBV circulating among Mongolian patients has not been reported. To obtain the complete nucleotide sequence of the Mongolian HBV, viral DNA was extracted from sera of patients with HBV infection. Six Mongolian HBV strains were amplified by PCR. Complete genomic sequences were determined for two Mongolian HBV isolates, MBT181 and MMU36. The entire genome of Mongolian HBV isolates was 3,182 bp long and genetic distance between Mongolian HBV isolates was 3.2%. Precore stop codon resulting from a guanine to adenine mutation at nucleotide 1,896 was detected in MBT181 strain. Based on phylogenetic analysis, the six Mongolian isolates were classified as genotype D.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalVirus Genes
Volume33
Issue number3
DOIs
Publication statusPublished - 2006 Dec 1

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Keywords

  • Genotype
  • Hepatitis
  • Hepatitis B virus
  • Mongolia
  • Phylogenetic analysis
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Virology
  • Molecular Biology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics

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