Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea

Zagaa Odgerel, Kyung Bo Nho, Ju Young Moon, Sun Ho Kee, Kwang Sook Park, Ki Joon Song, Luck Ju Baek, Jong Eun Yeon, Kwan Soo Byun, Chang Hong Lee, Jin Won Song

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalJournal of Medical Virology
Volume71
Issue number4
DOIs
Publication statusPublished - 2003 Dec

Keywords

  • Chronic hepatitis
  • HBV genotype
  • Phylogeny
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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