Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome

Jin Ju Kim, Kyu Ri Hwang, Young Min Choi, Shin Yong Moon, Soo Jin Chae, Chan Woo Park, Hye Ok Kim, Doo Seok Choi, Hyuck Chan Kwon, Byung Moon Kang, Byung Seok Lee, Si Hyun Cho, Tai June Kim, Tak Kim, Min Ju Kim, Hyun Young Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. Design Observational study. Setting Three infertility clinics and 10 university hospitals. Patient(s) Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. Intervention(s) Standardized evaluation protocol and web-based case report form. Main Outcome Measure(s) Metabolic and phenotypic profiles. Result(s) The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. Conclusion(s) Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.

Original languageEnglish
JournalFertility and Sterility
Volume101
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Metabolome
Polycystic Ovary Syndrome
Prediabetic State
Infertility
Hirsutism
Abdominal Obesity
Glucose Tolerance Test
Dyslipidemias
Observational Studies
Registries
Fasting
Hemoglobins
Obesity
Outcome Assessment (Health Care)
Hypertension
Glucose

Keywords

  • Metabolic syndrome
  • phenotype
  • polycystic ovary syndrome
  • Rotterdam criteria
  • type 2 diabetes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome. / Kim, Jin Ju; Hwang, Kyu Ri; Choi, Young Min; Moon, Shin Yong; Chae, Soo Jin; Park, Chan Woo; Kim, Hye Ok; Choi, Doo Seok; Kwon, Hyuck Chan; Kang, Byung Moon; Lee, Byung Seok; Cho, Si Hyun; Kim, Tai June; Kim, Tak; Kim, Min Ju; Park, Hyun Young.

In: Fertility and Sterility, Vol. 101, No. 5, 01.01.2014.

Research output: Contribution to journalArticle

Kim, JJ, Hwang, KR, Choi, YM, Moon, SY, Chae, SJ, Park, CW, Kim, HO, Choi, DS, Kwon, HC, Kang, BM, Lee, BS, Cho, SH, Kim, TJ, Kim, T, Kim, MJ & Park, HY 2014, 'Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome', Fertility and Sterility, vol. 101, no. 5. https://doi.org/10.1016/j.fertnstert.2014.01.049
Kim, Jin Ju ; Hwang, Kyu Ri ; Choi, Young Min ; Moon, Shin Yong ; Chae, Soo Jin ; Park, Chan Woo ; Kim, Hye Ok ; Choi, Doo Seok ; Kwon, Hyuck Chan ; Kang, Byung Moon ; Lee, Byung Seok ; Cho, Si Hyun ; Kim, Tai June ; Kim, Tak ; Kim, Min Ju ; Park, Hyun Young. / Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome. In: Fertility and Sterility. 2014 ; Vol. 101, No. 5.
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AU - Hwang, Kyu Ri

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AU - Moon, Shin Yong

AU - Chae, Soo Jin

AU - Park, Chan Woo

AU - Kim, Hye Ok

AU - Choi, Doo Seok

AU - Kwon, Hyuck Chan

AU - Kang, Byung Moon

AU - Lee, Byung Seok

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N2 - Objective To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. Design Observational study. Setting Three infertility clinics and 10 university hospitals. Patient(s) Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. Intervention(s) Standardized evaluation protocol and web-based case report form. Main Outcome Measure(s) Metabolic and phenotypic profiles. Result(s) The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. Conclusion(s) Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.

AB - Objective To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. Design Observational study. Setting Three infertility clinics and 10 university hospitals. Patient(s) Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. Intervention(s) Standardized evaluation protocol and web-based case report form. Main Outcome Measure(s) Metabolic and phenotypic profiles. Result(s) The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. Conclusion(s) Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.

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KW - type 2 diabetes

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