Complete regression of choroidal metastasis secondary to non-small-cell lung cancer with intravitreal bevacizumab and oral erlotinib combination therapy

Seong Woo Kim, Myung Jin Kim, Kuhl Huh, Jaeryung Oh

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    Purpose: To report a case of a complete regression of choroidal metastasis secondary to non-small-cell lung cancer (NSCLC). Methods: Retrospective case review of a female patient treated with intravitreal bevacizumab and oral erlotinib combination therapy for choroidal metastases secondary to NSCLC. Best corrected visual acuity (BCVA), fluorescein angiography (FA), optical coherence tomography (OCT), and B-scan ultrasonography were compared during the 4-month treatment period. Results: Four weeks after the third injection of bevacizumab (2.5 mg), the BCVA had improved to 20/40 from 20/200 and the 2 subretinal masses had completely disappeared. FA demonstrated only a retinal pigment epithelial (RPE) window defect with minimal to no leakage. In the B-scan ultrasonography and OCT, no further mass-like lesion was detected. The retina and RPE layer were flattened. Conclusion: Combining intravitreal bevacizumab and oral erlotinib could be another treatment option for patients with choroidal metastasis of NSCLC.

    Original languageEnglish
    Pages (from-to)411-413
    Number of pages3
    JournalOphthalmologica
    Volume223
    Issue number6
    DOIs
    Publication statusPublished - 2009 Oct

    Keywords

    • Bevacizumab
    • Choroidal metastasis
    • Erlotinib
    • Non-small-cell lung cancer

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems

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