Complex adaptive therapeutic strategy (CATS) for cancer

Yong Woo Cho, Sang Yoon Kim, Ick Chan Kwon, In-San Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra- and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system (CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalJournal of Controlled Release
Volume175
Issue number1
DOIs
Publication statusPublished - 2014 Feb 10

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Neoplasms
Therapeutics
Tumor Microenvironment
Artifacts
Clone Cells
Mutation

Keywords

  • Cancer immunotherapy
  • Complex adaptive system (CAS)
  • Induced phenotype
  • Nanoparticle
  • Tumor heterogeneity
  • Tumor network

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Complex adaptive therapeutic strategy (CATS) for cancer. / Cho, Yong Woo; Kim, Sang Yoon; Kwon, Ick Chan; Kim, In-San.

In: Journal of Controlled Release, Vol. 175, No. 1, 10.02.2014, p. 43-47.

Research output: Contribution to journalArticle

Cho, Yong Woo ; Kim, Sang Yoon ; Kwon, Ick Chan ; Kim, In-San. / Complex adaptive therapeutic strategy (CATS) for cancer. In: Journal of Controlled Release. 2014 ; Vol. 175, No. 1. pp. 43-47.
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