Abstract
The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.
| Original language | English |
|---|---|
| Pages (from-to) | 781-788 |
| Number of pages | 8 |
| Journal | Food Science and Biotechnology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 Jun 1 |
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Keywords
- Constipation
- Crypt cell
- GOS
- Lactulose
- Oligosaccharides
- Short-chain fatty acids
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
Cite this
Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats. / Kwon, Jung Il; Park, Yooheon; Noh, Dong Ouk; Suh, Hyung Joo; Han, Sung Hee.
In: Food Science and Biotechnology, Vol. 27, No. 3, 01.06.2018, p. 781-788.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats
AU - Kwon, Jung Il
AU - Park, Yooheon
AU - Noh, Dong Ouk
AU - Suh, Hyung Joo
AU - Han, Sung Hee
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.
AB - The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.
KW - Constipation
KW - Crypt cell
KW - GOS
KW - Lactulose
KW - Oligosaccharides
KW - Short-chain fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85047664059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047664059&partnerID=8YFLogxK
U2 - 10.1007/s10068-017-0300-2
DO - 10.1007/s10068-017-0300-2
M3 - Article
AN - SCOPUS:85047664059
VL - 27
SP - 781
EP - 788
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
SN - 1226-7708
IS - 3
ER -