Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

Jung Il Kwon, Yooheon Park, Dong Ouk Noh, Hyung Joo Suh, Sung Hee Han

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalFood Science and Biotechnology
Volume27
Issue number3
DOIs
Publication statusPublished - 2018 Jun 1

Keywords

  • Constipation
  • Crypt cell
  • GOS
  • Lactulose
  • Oligosaccharides
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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