Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

Jung Il Kwon, Yooheon Park, Dong Ouk Noh, Hyung Joo Suh, Sung Hee Han

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalFood Science and Biotechnology
Volume27
Issue number3
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Loperamide
galactooligosaccharides
Lactulose
lactulose
constipation
Constipation
Oligosaccharides
oligosaccharides
rats
Interstitial Cells of Cajal
peristalsis
Peristalsis
Bifidobacterium
Volatile Fatty Acids
short chain fatty acids
Insurance Benefits
dosage
Small Intestine
colon
gastrointestinal system

Keywords

  • Constipation
  • Crypt cell
  • GOS
  • Lactulose
  • Oligosaccharides
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats. / Kwon, Jung Il; Park, Yooheon; Noh, Dong Ouk; Suh, Hyung Joo; Han, Sung Hee.

In: Food Science and Biotechnology, Vol. 27, No. 3, 01.06.2018, p. 781-788.

Research output: Contribution to journalArticle

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