Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

Jung Il Kwon; Yooheon Park; Dong Ouk Noh; Hyung Joo Suh; Sung Hee Han

doi:10.1007/s10068-017-0300-2

Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

Jung Il Kwon, Yooheon Park, Dong Ouk Noh, Hyung Joo Suh, Sung Hee Han

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.

Original language	English
Pages (from-to)	781-788
Number of pages	8
Journal	Food Science and Biotechnology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s10068-017-0300-2
Publication status	Published - 2018 Jun 1

Keywords

Constipation
Crypt cell
GOS
Lactulose
Oligosaccharides
Short-chain fatty acids

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

Access to Document

10.1007/s10068-017-0300-2

Cite this

@article{73ef0d8eeb01474ab4a36319d92df02b,

title = "Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats",

abstract = "The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.",

keywords = "Constipation, Crypt cell, GOS, Lactulose, Oligosaccharides, Short-chain fatty acids",

author = "Kwon, {Jung Il} and Yooheon Park and Noh, {Dong Ouk} and Suh, {Hyung Joo} and Han, {Sung Hee}",

note = "Funding Information: This research was supported by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs. The authors declare that they have no conflict of interest. Publisher Copyright: {\textcopyright} 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.",

year = "2018",

month = jun,

day = "1",

doi = "10.1007/s10068-017-0300-2",

language = "English",

volume = "27",

pages = "781--788",

journal = "Food Science and Biotechnology",

issn = "1226-7708",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

AU - Kwon, Jung Il

AU - Park, Yooheon

AU - Noh, Dong Ouk

AU - Suh, Hyung Joo

AU - Han, Sung Hee

N1 - Funding Information: This research was supported by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs. The authors declare that they have no conflict of interest. Publisher Copyright: © 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.

AB - The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.

KW - Constipation

KW - Crypt cell

KW - GOS

KW - Lactulose

KW - Oligosaccharides

KW - Short-chain fatty acids

UR - http://www.scopus.com/inward/record.url?scp=85047664059&partnerID=8YFLogxK

U2 - 10.1007/s10068-017-0300-2

DO - 10.1007/s10068-017-0300-2

M3 - Article

AN - SCOPUS:85047664059

SN - 1226-7708

VL - 27

SP - 781

EP - 788

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 3

ER -

Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this