Computational dose predictions for combined treatment of hemofiltration with weekly hemodialysis

Jung Chan Lee, Chan Young Park, Seong Wook Choi, Joong Yull Park, Jeong Chul Kim, Young Min Yun, Kyoung Kap Lee, Kyung Sun, Byoung Goo Min

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hemodialysis (HD) has sufficient efficacy as a conventional diffusive treatment for removing small molecules, whereas hemofiltration (HF), which is a convective treatment, has an improved the clearance of intermediate-sized molecules. This paper reports a combined treatment (CT) which combines the diffusive and convective efficacies of HF several times weekly with HD weekly. CT modalities with various schedules and prescriptions are described mathematically using a variable-volume two-compartment kinetics model, and the kinetic parameters were obtained from previous clinical reports and a hemodialysis-related database. The blood concentration profiles of the three waste molecules for 52 weeks were calculated in order to compare the capability of removing small and intermediate-sized molecules to those of other renal treatments. The results by a computer simulation show that CT can reduce the frequency of sessions and the volume of replacement fluid compared with daily convective treatment, and achieve the adequate treatment efficiency with both small and intermediate-sized molecules for chronic renal failure patients.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalComputer Methods and Programs in Biomedicine
Volume89
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Hemofiltration
Renal Dialysis
Molecules
Therapeutics
Kinetic parameters
Blood
Kinetics
Fluids
Computer Simulation
Chronic Kidney Failure
Prescriptions
Computer simulation
Appointments and Schedules
Databases
Kidney

Keywords

  • Combined treatment
  • Dose prediction
  • Hemodialysis
  • Hemofiltration
  • Kinetics model

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

Cite this

Computational dose predictions for combined treatment of hemofiltration with weekly hemodialysis. / Lee, Jung Chan; Park, Chan Young; Choi, Seong Wook; Park, Joong Yull; Kim, Jeong Chul; Yun, Young Min; Lee, Kyoung Kap; Sun, Kyung; Min, Byoung Goo.

In: Computer Methods and Programs in Biomedicine, Vol. 89, No. 3, 01.03.2008, p. 275-281.

Research output: Contribution to journalArticle

Lee, Jung Chan ; Park, Chan Young ; Choi, Seong Wook ; Park, Joong Yull ; Kim, Jeong Chul ; Yun, Young Min ; Lee, Kyoung Kap ; Sun, Kyung ; Min, Byoung Goo. / Computational dose predictions for combined treatment of hemofiltration with weekly hemodialysis. In: Computer Methods and Programs in Biomedicine. 2008 ; Vol. 89, No. 3. pp. 275-281.
@article{6880fe7dd736411eb5b662c8bab45367,
title = "Computational dose predictions for combined treatment of hemofiltration with weekly hemodialysis",
abstract = "Hemodialysis (HD) has sufficient efficacy as a conventional diffusive treatment for removing small molecules, whereas hemofiltration (HF), which is a convective treatment, has an improved the clearance of intermediate-sized molecules. This paper reports a combined treatment (CT) which combines the diffusive and convective efficacies of HF several times weekly with HD weekly. CT modalities with various schedules and prescriptions are described mathematically using a variable-volume two-compartment kinetics model, and the kinetic parameters were obtained from previous clinical reports and a hemodialysis-related database. The blood concentration profiles of the three waste molecules for 52 weeks were calculated in order to compare the capability of removing small and intermediate-sized molecules to those of other renal treatments. The results by a computer simulation show that CT can reduce the frequency of sessions and the volume of replacement fluid compared with daily convective treatment, and achieve the adequate treatment efficiency with both small and intermediate-sized molecules for chronic renal failure patients.",
keywords = "Combined treatment, Dose prediction, Hemodialysis, Hemofiltration, Kinetics model",
author = "Lee, {Jung Chan} and Park, {Chan Young} and Choi, {Seong Wook} and Park, {Joong Yull} and Kim, {Jeong Chul} and Yun, {Young Min} and Lee, {Kyoung Kap} and Kyung Sun and Min, {Byoung Goo}",
year = "2008",
month = "3",
day = "1",
doi = "10.1016/j.cmpb.2007.11.004",
language = "English",
volume = "89",
pages = "275--281",
journal = "Computer Methods and Programs in Biomedicine",
issn = "0169-2607",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Computational dose predictions for combined treatment of hemofiltration with weekly hemodialysis

AU - Lee, Jung Chan

AU - Park, Chan Young

AU - Choi, Seong Wook

AU - Park, Joong Yull

AU - Kim, Jeong Chul

AU - Yun, Young Min

AU - Lee, Kyoung Kap

AU - Sun, Kyung

AU - Min, Byoung Goo

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Hemodialysis (HD) has sufficient efficacy as a conventional diffusive treatment for removing small molecules, whereas hemofiltration (HF), which is a convective treatment, has an improved the clearance of intermediate-sized molecules. This paper reports a combined treatment (CT) which combines the diffusive and convective efficacies of HF several times weekly with HD weekly. CT modalities with various schedules and prescriptions are described mathematically using a variable-volume two-compartment kinetics model, and the kinetic parameters were obtained from previous clinical reports and a hemodialysis-related database. The blood concentration profiles of the three waste molecules for 52 weeks were calculated in order to compare the capability of removing small and intermediate-sized molecules to those of other renal treatments. The results by a computer simulation show that CT can reduce the frequency of sessions and the volume of replacement fluid compared with daily convective treatment, and achieve the adequate treatment efficiency with both small and intermediate-sized molecules for chronic renal failure patients.

AB - Hemodialysis (HD) has sufficient efficacy as a conventional diffusive treatment for removing small molecules, whereas hemofiltration (HF), which is a convective treatment, has an improved the clearance of intermediate-sized molecules. This paper reports a combined treatment (CT) which combines the diffusive and convective efficacies of HF several times weekly with HD weekly. CT modalities with various schedules and prescriptions are described mathematically using a variable-volume two-compartment kinetics model, and the kinetic parameters were obtained from previous clinical reports and a hemodialysis-related database. The blood concentration profiles of the three waste molecules for 52 weeks were calculated in order to compare the capability of removing small and intermediate-sized molecules to those of other renal treatments. The results by a computer simulation show that CT can reduce the frequency of sessions and the volume of replacement fluid compared with daily convective treatment, and achieve the adequate treatment efficiency with both small and intermediate-sized molecules for chronic renal failure patients.

KW - Combined treatment

KW - Dose prediction

KW - Hemodialysis

KW - Hemofiltration

KW - Kinetics model

UR - http://www.scopus.com/inward/record.url?scp=38649107820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38649107820&partnerID=8YFLogxK

U2 - 10.1016/j.cmpb.2007.11.004

DO - 10.1016/j.cmpb.2007.11.004

M3 - Article

VL - 89

SP - 275

EP - 281

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

SN - 0169-2607

IS - 3

ER -