Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy

Ju Han Song, Kyung Min Cho, Hyeoung Joon Kim, Yeo Kyeoung Kim, Nan Young Kim, Hee J.E. Kim, Tae Hyang Lee, Seung Yong Hwang, Tae Sung Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Although acute myeloid leukemia (AML) exhibits diverse responses to chemotherapy, patients harboring the t(8;21) translocation are part of a favorable risk group. However, the reason why this subgroup is more responsive to cytarabine-based therapy has not been elucidated. In the present study, we analyzed expression levels of cytarabine metabolism-related genes in patients diagnosed with AML with or without t(8;21) and investigated their correlation with clinical outcomes after cytarabine-based therapy. Among the 8 genes studied, expression of the concentrative nucleoside transporter 3 (CNT3) gene was significantly higher in t(8;21)-positive patients compared to the others in the test population and the validation cohort (P<0.001 in Mann-Whitney U test; P<0.002 in Pearson's correlation analysis). Additionally, in both multivariate and univariate analyses, t(8;21)-positive patients categorized in a higher CNT3 expression tertile had longer disease-free survival [hazard ratio (HR), 0.117; 95% confidence interval (CI), 0.025-0.557; P=0.008] and overall survival (HR, 0.062; 95% CI, 0.007-0.521; P=0.010) compared to t(8;21)-positive patients in a lower CNT3 expression tertile. Notably, these trends did not occur in t(8;21)-negative patients. Our results demonstrate that CNT3 expression is associated with overall favorable outcomes and is predictive of clinical outcomes in AML patients with t(8;21). This suggests that CNT3 expression can be used to optimize treatment strategies for AML patients.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalOncology reports
Volume34
Issue number1
DOIs
Publication statusPublished - 2015 Jul 1

Keywords

  • Acute myeloid leukemia
  • CNT3
  • Cytarabine
  • Prognosis
  • t(8;21) translocation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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