Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers

Jin Kyung Jeon, Hyunseon Seo, Jimin Park, Soo Ji Son, Yeong Rim Kim, Eun Shil Kim, Jong Woong Park, Woong Gyo Jung, Hojeong Jeon, Yu Chan Kim, Hyun Kwang Seok, Jae Ho Shin, Myoung Ryul Ok

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implants because the device loses its fixation strength before the fractured bone heals. This study suggests a new approach to overcome this hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is an essential process in early bone regeneration, a Mg implant coated with electrospun nanofibers containing nitric oxide (NO), which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to be stored on the NO donor-conjugated nanofiber coating, stably delivered, and released to the fractured bone tissue near the implanted sites. An in vitro corrosion test reveals no adverse effect of the released NO on the corrosion behavior of the Mg implant. Simultaneously, the optimal concentration level of NO released from the implant significantly enhances tube network formation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis can be accelerated by combining NO-releasing nanofibers with a Mg implant. With its proven feasibility, the proposed approach could be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fixation.

Original languageEnglish
JournalMetals and Materials International
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Nitric oxide
releasing
nitric oxide
Nanofibers
Magnesium
magnesium
Nitric Oxide
Tissue
Bone
angiogenesis
bones
regeneration
Corrosion
corrosion
Tissue regeneration
Nitric Oxide Donors
Endothelial cells
biodegradation
Cytotoxicity
corrosion tests

Keywords

  • Angiogenesis
  • Biodegradable magnesium implant
  • Bone regeneration
  • Nanofiber
  • Nitric oxide

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Metals and Alloys
  • Materials Chemistry

Cite this

Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers. / Jeon, Jin Kyung; Seo, Hyunseon; Park, Jimin; Son, Soo Ji; Kim, Yeong Rim; Kim, Eun Shil; Park, Jong Woong; Jung, Woong Gyo; Jeon, Hojeong; Kim, Yu Chan; Seok, Hyun Kwang; Shin, Jae Ho; Ok, Myoung Ryul.

In: Metals and Materials International, 01.01.2019.

Research output: Contribution to journalArticle

Jeon, Jin Kyung ; Seo, Hyunseon ; Park, Jimin ; Son, Soo Ji ; Kim, Yeong Rim ; Kim, Eun Shil ; Park, Jong Woong ; Jung, Woong Gyo ; Jeon, Hojeong ; Kim, Yu Chan ; Seok, Hyun Kwang ; Shin, Jae Ho ; Ok, Myoung Ryul. / Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers. In: Metals and Materials International. 2019.
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