Concise catalytic asymmetric total syntheses of ancistrocladinium A and its atropdiastereomer

Kyung Hee Kim, Cheol-Hong Cheon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Asymmetric total syntheses of ancistrocladinium A and its atropdiastereomer, in an atropisomerically pure form, are described. Chiral phosphoric acid-catalyzed asymmetric reductive amination of 1-aryl propanone and naphthylamine followed by acetylation provided two atropisomerically pure tertiary amides. Subsequent stereospecific Bischler-Napieralski reaction of each of these tertiary amides with triflic anhydride provided ancistrocladinium A or its atropdiastereomer, as a single atropisomer, respectively.

Original languageEnglish
Pages (from-to)1341-1349
Number of pages9
JournalOrganic Chemistry Frontiers
Volume4
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

ASJC Scopus subject areas

  • Organic Chemistry

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