Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

Yong Un Kang, Min Jee Kim, Joon Seok Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Young Keun Ahn, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Soo Wan Kim, Myung Ho Jeong, Young Keun Ahn, Sung Chull Chae, Jong Hyun Kim, Seung Ho Hur, Young Jo Kim, In Whan Seong, Dong Hoon ChoiJei Keon Chae, Taek Jong Hong, Jae Young Rhew, Doo Il Kim, In Ho Chae, Jung Han Yoon, Bon Kwon Koo, Byung Ok Kim, Myoung Yong Lee, Kee Sik Kim, Jin Yong Hwang, Myeong Chan Cho, Seok Kyu Oh, Nae Hee Lee, Kyoung Tae Jeong, Seung Jea Tahk, Jang Ho Bae, Seung Woon Rha, Keum Soo Park, Chong Jin Kim, Kyoo Rok Han, Tae Hoon Ahn, Moo Hyun Kim, Ki Bae Seung, Wook Sung Chung, Ju Young Yang, Chong Yun Rhim, Hyeon Cheol Gwon, Seong Wook Park, Young Youp Koh, Seung Jae Joo, Soo Joong Kim, Dong Kyu Jin, Jin Man Cho, Byung Ok Kim, Sang Wook Kim, Jeong Kyung Kim, Tae Ik Kim, Deug Young Nah, Si Hoon Park, Sang Hyun Lee, Seung Uk Lee, Hang Jae Chung, Jang Hyun Cho, Seung Won Jin, Yang Soo Jang, Jeong Gwan Cho, Seung Jung Park

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Abstract

Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min-1·1.73 m-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalYonsei Medical Journal
Volume55
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Keywords

  • C-reactive protein
  • Glomerular filtration rate
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kang, Y. U., Kim, M. J., Choi, J. S., Kim, C. S., Bae, E. H., Ma, S. K., Ahn, Y. K., Jeong, M. H., Kim, Y. J., Cho, M. C., Kim, C. J., Kim, S. W., Jeong, M. H., Ahn, Y. K., Chae, S. C., Kim, J. H., Hur, S. H., Kim, Y. J., Seong, I. W., ... Park, S. J. (2014). Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction. Yonsei Medical Journal, 55(1), 132-140. https://doi.org/10.3349/ymj.2014.55.1.132