Concurrent benzodiazepine use in older adults treated with antidepressants in Asia

Xiao Mei Zhong, Fei Wang, Qinge Zhang, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Tian Mei Si, Kang Sim, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Kok Yoon Chee, Shigenobu Kanba, Min-Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy A. Kallivayalil, Andi J. Tanra, Margarita M. Maramis, Winston W. ShenNorman Sartorius, Rathi Mahendran, Chay Hoon Tan, Naotaka Shinfuku, Yu Tao Xiang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background:: Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. Methods:: The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed. Results:: The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants. Conclusions:: Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Psychogeriatrics
DOIs
Publication statusAccepted/In press - 2017 Dec 7

Fingerprint

Benzodiazepines
Antidepressive Agents
Prescriptions
Psychiatry
Logistic Models
Regression Analysis
Demography
Public Hospitals
Inpatients
Databases
Research

Keywords

  • antidepressant
  • Asia
  • benzodiazepines
  • older adults

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Zhong, X. M., Wang, F., Zhang, Q., Ungvari, G. S., Ng, C. H., Chiu, H. F. K., ... Xiang, Y. T. (Accepted/In press). Concurrent benzodiazepine use in older adults treated with antidepressants in Asia. International Psychogeriatrics, 1-7. https://doi.org/10.1017/S1041610217002563

Concurrent benzodiazepine use in older adults treated with antidepressants in Asia. / Zhong, Xiao Mei; Wang, Fei; Zhang, Qinge; Ungvari, Gabor S.; Ng, Chee H.; Chiu, Helen F.K.; Si, Tian Mei; Sim, Kang; Avasthi, Ajit; Grover, Sandeep; Chong, Mian Yoon; Chee, Kok Yoon; Kanba, Shigenobu; Lee, Min-Soo; Yang, Shu Yu; Udomratn, Pichet; Kallivayalil, Roy A.; Tanra, Andi J.; Maramis, Margarita M.; Shen, Winston W.; Sartorius, Norman; Mahendran, Rathi; Tan, Chay Hoon; Shinfuku, Naotaka; Xiang, Yu Tao.

In: International Psychogeriatrics, 07.12.2017, p. 1-7.

Research output: Contribution to journalArticle

Zhong, XM, Wang, F, Zhang, Q, Ungvari, GS, Ng, CH, Chiu, HFK, Si, TM, Sim, K, Avasthi, A, Grover, S, Chong, MY, Chee, KY, Kanba, S, Lee, M-S, Yang, SY, Udomratn, P, Kallivayalil, RA, Tanra, AJ, Maramis, MM, Shen, WW, Sartorius, N, Mahendran, R, Tan, CH, Shinfuku, N & Xiang, YT 2017, 'Concurrent benzodiazepine use in older adults treated with antidepressants in Asia', International Psychogeriatrics, pp. 1-7. https://doi.org/10.1017/S1041610217002563
Zhong, Xiao Mei ; Wang, Fei ; Zhang, Qinge ; Ungvari, Gabor S. ; Ng, Chee H. ; Chiu, Helen F.K. ; Si, Tian Mei ; Sim, Kang ; Avasthi, Ajit ; Grover, Sandeep ; Chong, Mian Yoon ; Chee, Kok Yoon ; Kanba, Shigenobu ; Lee, Min-Soo ; Yang, Shu Yu ; Udomratn, Pichet ; Kallivayalil, Roy A. ; Tanra, Andi J. ; Maramis, Margarita M. ; Shen, Winston W. ; Sartorius, Norman ; Mahendran, Rathi ; Tan, Chay Hoon ; Shinfuku, Naotaka ; Xiang, Yu Tao. / Concurrent benzodiazepine use in older adults treated with antidepressants in Asia. In: International Psychogeriatrics. 2017 ; pp. 1-7.
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