Obstructive sleep apnea (OSA) leads to multiple end-organ morbidities that are mediated by the cumulative burden of oxidative stress and inflammation. Both OSA and inflammation play key roles in increased risk of cardiovascular disease (CVD). Thus, we hypothesized that the combination of inflammation and OSA could accelerate the development of metabolic syndrome (MetS) in a large cohort study. A total of 1835 participants were randomly selected from the ongoing Korean Genome and Epidemiology Study for the years between 2007 and 2015. Overnight polysomnography was performed on each participant. Blood was drawn for biochemical analyses. Participants with high or low inflammation were divided by high-sensitivity C-reactive protein (hsCRP). MetS was defined using the criteria of the modified National Cholesterol Education Program, Adult Treatment Panel III. The prevalence ofMetSwas higheramong the subjects withOSAand high hsCRPlevels than among the other corresponding groups. The incidence ofMetSamong the 4 groups stratified byOSA and inflammation status at the 6-year follow-up was 11.8%, 19.9%, 25.8%, and 36.0%(HsCRP[-]/OSA[-] vsHsCRP[+]/OSA[-] vsHsCRP[-]/OSA[+] vs HsCRP[+]/OSA[+], P<0.01). After adjusting for age, sex, smoking, alcohol status,BMI, and change inBMI (DBMI) in amultiple logistic regression, the subjectswithOSA and high hsCRP levels at follow-up had a 2.22-fold risk of developing MetS, as compared with those with no-OSA and low hsCRP levels (P<0.01). MetS is more prevalent in the concurrent presence of inflammation and OSA. The combination of these conditions is associated with higher risk of MetS. Additional research is needed to help further define the significance of the combined effect of OSA and subclinical inflammation on the development of MetS in the context of reduction of CVD risk.
- Cardiovascular disease
- High-sensitivity C-reactive protein
- Metabolic syndrome
- Obstructive sleep apnea
ASJC Scopus subject areas