Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice

Jae Gwang Song, Osung Kwon, Eun Mi Hwang, Hyung Wook Kim, Jae Yong Park

Research output: Contribution to journalArticlepeer-review

Abstract

The medial habenula (mHb), a subregion of the habenula, is involved in diverse brain functions, such as nicotine addiction, anxiety, and anhedonia. We recently reported that TMEM16A deficiency, a calcium-activated chloride channel, decreased the activity of mHb cholinergic neurons. Since downregulated activity in cholinergic neurons of the mHb is involved in anhedonia-like behavior, we here investigated whether conditional deletion of TMEM16A in mHb cholinergic neurons also displays anhedonia-like behavior. The conditional deletion of TMEM16A in the mHb cholinergic neurons of mice (TMEM16A cKO mice) was generated by crossing ChaT-Cre (+) with floxed TMEM16A f/f mice. TMEM16A cKO mice displayed significantly reduced social interaction, sucrose preference, female urine sniffing, and increased marble burying. These behavioral data suggest the potential role of TMEM16A in anhedonic-like behavior in mice. Taken together, the presented data suggest that TMEM16A-mediated mHb activity might be a therapeutic target for anhedonia-related symptoms.

Original languageEnglish
Article number113841
JournalBehavioural Brain Research
Volume426
DOIs
Publication statusPublished - 2022 May 24

Keywords

  • Anhedonia
  • Cholinergic neuron
  • Medial habenula
  • TMEM16A

ASJC Scopus subject areas

  • Behavioral Neuroscience

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