Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

Yongseok Choi, Ji Hye Kang, Nancy E. Lewin, Peter M. Blumberg, Jeewoo Lee, Victor E. Marquez

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The structures of N-hydroxylamides la and lb, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. Here, we report the synthesis and complete characterization of 1a and 1b together with the associated biological activity in terms of PK-C binding affinity.

Original languageEnglish
Pages (from-to)2790-2793
Number of pages4
JournalJournal of Medicinal Chemistry
Volume46
Issue number13
DOIs
Publication statusPublished - 2003 Jun 19
Externally publishedYes

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Bearings (structural)
Diglycerides
Lactones
Protein Kinase C
Bioactivity
Esters
Ligands

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. / Choi, Yongseok; Kang, Ji Hye; Lewin, Nancy E.; Blumberg, Peter M.; Lee, Jeewoo; Marquez, Victor E.

In: Journal of Medicinal Chemistry, Vol. 46, No. 13, 19.06.2003, p. 2790-2793.

Research output: Contribution to journalArticle

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AU - Blumberg, Peter M.

AU - Lee, Jeewoo

AU - Marquez, Victor E.

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