Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

Yongseok Choi; Ji Hye Kang; Nancy E. Lewin; Peter M. Blumberg; Jeewoo Lee; Victor E. Marquez

doi:10.1021/jm030082c

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

Yongseok Choi, Ji Hye Kang, Nancy E. Lewin, Peter M. Blumberg, Jeewoo Lee, Victor E. Marquez

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The structures of N-hydroxylamides la and lb, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. Here, we report the synthesis and complete characterization of 1a and 1b together with the associated biological activity in terms of PK-C binding affinity.

Original language	English
Pages (from-to)	2790-2793
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	46
Issue number	13
DOIs	https://doi.org/10.1021/jm030082c
Publication status	Published - 2003 Jun 19
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. / Choi, Yongseok; Kang, Ji Hye; Lewin, Nancy E. et al.

In: Journal of Medicinal Chemistry, Vol. 46, No. 13, 19.06.2003, p. 2790-2793.

Research output: Contribution to journal › Article › peer-review

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AU - Blumberg, Peter M.

AU - Lee, Jeewoo

AU - Marquez, Victor E.

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Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

Abstract

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