The structures of N-hydroxylamides la and lb, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. Here, we report the synthesis and complete characterization of 1a and 1b together with the associated biological activity in terms of PK-C binding affinity.
|Number of pages||4|
|Journal||Journal of Medicinal Chemistry|
|Publication status||Published - 2003 Jun 19|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery