Congenital varicella syndrome: A systematic review

Ki Hoon Ahn; Yun Jung Park; Soon Cheol Hong; Eun Hee Lee; Ji Sung Lee; Min Jeong Oh; Hai Joong Kim

doi:10.3109/01443615.2015.1127905

Congenital varicella syndrome: A systematic review

Ki Hoon Ahn, Yun Jung Park, Soon Cheol Hong, Eun Hee Lee, Ji Sung Lee, Min Jeong Oh, Hai Joong Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21–27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.

Original language	English
Pages (from-to)	563-566
Number of pages	4
Journal	Journal of Obstetrics and Gynaecology
Volume	36
Issue number	5
DOIs	https://doi.org/10.3109/01443615.2015.1127905
Publication status	Published - 2016 Jul 3

Keywords

Chickenpox
congenital varicella syndrome
herpes zoster
pregnancy

ASJC Scopus subject areas

Obstetrics and Gynaecology

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10.3109/01443615.2015.1127905

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title = "Congenital varicella syndrome: A systematic review",

abstract = "Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21–27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.",

keywords = "Chickenpox, congenital varicella syndrome, herpes zoster, pregnancy",

author = "Ahn, {Ki Hoon} and Park, {Yun Jung} and Hong, {Soon Cheol} and Lee, {Eun Hee} and Lee, {Ji Sung} and Oh, {Min Jeong} and Kim, {Hai Joong}",

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T2 - A systematic review

AU - Ahn, Ki Hoon

AU - Park, Yun Jung

AU - Hong, Soon Cheol

AU - Lee, Eun Hee

AU - Lee, Ji Sung

AU - Oh, Min Jeong

AU - Kim, Hai Joong

PY - 2016/7/3

Y1 - 2016/7/3

N2 - Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21–27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.

AB - Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21–27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.

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KW - congenital varicella syndrome

KW - herpes zoster

KW - pregnancy

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Congenital varicella syndrome: A systematic review

Abstract

Keywords

ASJC Scopus subject areas

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