TY - GEN
T1 - Connectomics signature for characterizaton of mild cognitive impairment and schizophrenia
AU - Zhu, Dajiang
AU - Shen, Dinggang
AU - Jiang, Xi
AU - Liu, Tianming
PY - 2014/7/29
Y1 - 2014/7/29
N2 - Human connectomes constructed via neuroimaging data offer a comprehensive description of the macro-scale structural connectivity within the brain. Thus quantitative assessment of connectome-scale structural and functional connectivities will not only fundamentally advance our understanding of normal brain organization and function, but also have significant importance to systematically and comprehensively characterize many devastating brain conditions. In recognition of the importance of connectome and connectomics, in this paper, we develop and evaluate a novel computational framework to construct structural connectomes from diffusion tensor imaging (DTI) data and assess connectome-scale functional connectivity alterations in mild cognitive impairment (MCI) and schizophrenia (SZ) from concurrent resting state fMRI (R-fMRI) data, in comparison with their healthy controls. By applying effective feature selection approaches, we discovered informative and robust functional connectomics signatures that can distinctively characterize and successfully differentiate the two brain conditions of MCI and SZ from their healthy controls (classification accuracies are 96% and 100%, respectively). Our results suggest that connectomics signatures could be a general, powerful methodology for characterization and classification of many brain conditions in the future.
AB - Human connectomes constructed via neuroimaging data offer a comprehensive description of the macro-scale structural connectivity within the brain. Thus quantitative assessment of connectome-scale structural and functional connectivities will not only fundamentally advance our understanding of normal brain organization and function, but also have significant importance to systematically and comprehensively characterize many devastating brain conditions. In recognition of the importance of connectome and connectomics, in this paper, we develop and evaluate a novel computational framework to construct structural connectomes from diffusion tensor imaging (DTI) data and assess connectome-scale functional connectivity alterations in mild cognitive impairment (MCI) and schizophrenia (SZ) from concurrent resting state fMRI (R-fMRI) data, in comparison with their healthy controls. By applying effective feature selection approaches, we discovered informative and robust functional connectomics signatures that can distinctively characterize and successfully differentiate the two brain conditions of MCI and SZ from their healthy controls (classification accuracies are 96% and 100%, respectively). Our results suggest that connectomics signatures could be a general, powerful methodology for characterization and classification of many brain conditions in the future.
KW - Connectome
KW - Network-based signature
UR - http://www.scopus.com/inward/record.url?scp=84920997857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920997857&partnerID=8YFLogxK
U2 - 10.1109/isbi.2014.6867874
DO - 10.1109/isbi.2014.6867874
M3 - Conference contribution
AN - SCOPUS:84920997857
T3 - 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
SP - 325
EP - 328
BT - 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
Y2 - 29 April 2014 through 2 May 2014
ER -