Abstract
Human connectomes constructed via neuroimaging data offer a comprehensive description of the macro-scale structural connectivity within the brain. Thus quantitative assessment of connectome-scale structural and functional connectivities will not only fundamentally advance our understanding of normal brain organization and function, but also have significant importance to systematically and comprehensively characterize many devastating brain conditions. In recognition of the importance of connectome and connectomics, in this paper, we develop and evaluate a novel computational framework to construct structural connectomes from diffusion tensor imaging (DTI) data and assess connectome-scale functional connectivity alterations in mild cognitive impairment (MCI) and schizophrenia (SZ) from concurrent resting state fMRI (R-fMRI) data, in comparison with their healthy controls. By applying effective feature selection approaches, we discovered informative and robust functional connectomics signatures that can distinctively characterize and successfully differentiate the two brain conditions of MCI and SZ from their healthy controls (classification accuracies are 96% and 100%, respectively). Our results suggest that connectomics signatures could be a general, powerful methodology for characterization and classification of many brain conditions in the future.
| Original language | English |
|---|---|
| Title of host publication | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 325-328 |
| Number of pages | 4 |
| ISBN (Print) | 9781467319591 |
| Publication status | Published - 2014 Jul 29 |
| Externally published | Yes |
| Event | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing, China Duration: 2014 Apr 29 → 2014 May 2 |
Other
| Other | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 |
|---|---|
| Country | China |
| City | Beijing |
| Period | 14/4/29 → 14/5/2 |
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Keywords
- Connectome
- Network-based signature
ASJC Scopus subject areas
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
Cite this
Connectomics signature for characterizaton of mild cognitive impairment and schizophrenia. / Zhu, Dajiang; Shen, Dinggang; Jiang, Xi; Liu, Tianming.
2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 325-328 6867874.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Connectomics signature for characterizaton of mild cognitive impairment and schizophrenia
AU - Zhu, Dajiang
AU - Shen, Dinggang
AU - Jiang, Xi
AU - Liu, Tianming
PY - 2014/7/29
Y1 - 2014/7/29
N2 - Human connectomes constructed via neuroimaging data offer a comprehensive description of the macro-scale structural connectivity within the brain. Thus quantitative assessment of connectome-scale structural and functional connectivities will not only fundamentally advance our understanding of normal brain organization and function, but also have significant importance to systematically and comprehensively characterize many devastating brain conditions. In recognition of the importance of connectome and connectomics, in this paper, we develop and evaluate a novel computational framework to construct structural connectomes from diffusion tensor imaging (DTI) data and assess connectome-scale functional connectivity alterations in mild cognitive impairment (MCI) and schizophrenia (SZ) from concurrent resting state fMRI (R-fMRI) data, in comparison with their healthy controls. By applying effective feature selection approaches, we discovered informative and robust functional connectomics signatures that can distinctively characterize and successfully differentiate the two brain conditions of MCI and SZ from their healthy controls (classification accuracies are 96% and 100%, respectively). Our results suggest that connectomics signatures could be a general, powerful methodology for characterization and classification of many brain conditions in the future.
AB - Human connectomes constructed via neuroimaging data offer a comprehensive description of the macro-scale structural connectivity within the brain. Thus quantitative assessment of connectome-scale structural and functional connectivities will not only fundamentally advance our understanding of normal brain organization and function, but also have significant importance to systematically and comprehensively characterize many devastating brain conditions. In recognition of the importance of connectome and connectomics, in this paper, we develop and evaluate a novel computational framework to construct structural connectomes from diffusion tensor imaging (DTI) data and assess connectome-scale functional connectivity alterations in mild cognitive impairment (MCI) and schizophrenia (SZ) from concurrent resting state fMRI (R-fMRI) data, in comparison with their healthy controls. By applying effective feature selection approaches, we discovered informative and robust functional connectomics signatures that can distinctively characterize and successfully differentiate the two brain conditions of MCI and SZ from their healthy controls (classification accuracies are 96% and 100%, respectively). Our results suggest that connectomics signatures could be a general, powerful methodology for characterization and classification of many brain conditions in the future.
KW - Connectome
KW - Network-based signature
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M3 - Conference contribution
SN - 9781467319591
SP - 325
EP - 328
BT - 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PB - Institute of Electrical and Electronics Engineers Inc.
ER -