Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea

Myung H. Nam, Jin W. Jang, Hanna Kim, Eun T. Han, Won J. Lee, Seong S.A. An, Ae S.D. Park, Chae S. Lim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) became one of the important vaccine candidates for malaria, because P. vivax TRAP (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal-1 strain. Sequencing analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.

Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalTropical Medicine and International Health
Volume16
Issue number8
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • Korea
  • Malaria vaccine
  • Plasmodium vivax
  • Polymorphism
  • Thrombospondin-related adhesive protein

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea'. Together they form a unique fingerprint.

  • Cite this