Construction of 4d neonatal cortical surface atlases using wasserstein distance

Zengsi Chen, Zhengwang Wu, Liang Sun, Fan Wang, Li Wang, Fenqiang Zhao, Weili Lin, John H. Gilmore, Dinggang Shen, Gang Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Spatiotemporal (4D) neonatal cortical surface atlases with densely sampled ages are important tools for understanding the dynamic early brain development. Conventionally, after non-linear co-registration, surface atlases are constructed by simple Euclidean average of cortical attributes across different subjects, which leads to blurred folding patterns and therefore hampers the reliability and accuracy when used to register new subjects. To better preserve the sharpness and clarity of cortical folding patterns on surface atlases, we propose to compute the Wasserstein barycenter, which represents a geometrically faithful population mean under the Wasserstein distance metric, for the construction of 4D neonatal surface atlases. Comparing to the direct vertex-wise Euclidean average, the Wasserstein distance takes into account the alignment of spatial distribution of cortical attributes, thus is robust to potential registration errors during atlas building. Using this method, we constructed 4D neonatal cortical surface atlases at each week, from 39 to 44 postmenstrual weeks, based on a large-scale dataset with 764 subjects. Our 4D atlases show sharper and more geometrically faithful cortical folding patterns compared to the state-of-the-art methods, thus leading to boosted accuracy when used to align new subjects and facilitating early brain development studies.

Original languageEnglish
Title of host publicationISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages995-998
Number of pages4
ISBN (Electronic)9781538636411
DOIs
Publication statusPublished - 2019 Apr
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: 2019 Apr 82019 Apr 11

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2019-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference16th IEEE International Symposium on Biomedical Imaging, ISBI 2019
CountryItaly
CityVenice
Period19/4/819/4/11

Keywords

  • Cortical folding
  • Infant surface atlases
  • Wasserstein distance

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Construction of 4d neonatal cortical surface atlases using wasserstein distance'. Together they form a unique fingerprint.

  • Cite this

    Chen, Z., Wu, Z., Sun, L., Wang, F., Wang, L., Zhao, F., Lin, W., Gilmore, J. H., Shen, D., & Li, G. (2019). Construction of 4d neonatal cortical surface atlases using wasserstein distance. In ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging (pp. 995-998). [8759557] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2019-April). IEEE Computer Society. https://doi.org/10.1109/ISBI.2019.8759557