Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy

Ming Kong, Hyun Jin Park, Chao Feng, Lin Hou, Xiaojie Cheng, Xiguang Chen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-Assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.

Original languageEnglish
Pages (from-to)634-641
Number of pages8
JournalCarbohydrate Polymers
Volume94
Issue number1
DOIs
Publication statusPublished - 2013 Apr 15

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Keywords

  • Hyaluronic acid
  • Niosome
  • Transdermal
  • Tumor therapy

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

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