Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy

Ming Kong; Hyunjin Park; Chao Feng; Lin Hou; Xiaojie Cheng; Xiguang Chen

doi:10.1016/j.carbpol.2013.01.091

Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy

Ming Kong, Hyunjin Park, Chao Feng, Lin Hou, Xiaojie Cheng, Xiguang Chen

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-Assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.

Original language	English
Pages (from-to)	634-641
Number of pages	8
Journal	Carbohydrate Polymers
Volume	94
Issue number	1
DOIs	https://doi.org/10.1016/j.carbpol.2013.01.091
Publication status	Published - 2013 Apr 15

Keywords

Hyaluronic acid
Niosome
Transdermal
Tumor therapy

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2013.01.091

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title = "Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy",

abstract = "To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-Assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.",

keywords = "Hyaluronic acid, Niosome, Transdermal, Tumor therapy",

author = "Ming Kong and Hyunjin Park and Chao Feng and Lin Hou and Xiaojie Cheng and Xiguang Chen",

note = "Funding Information: This study is supported by grant from NSFC ( 31240007 and 81271727 ) and Shandong Youth Scientist Awards Foundation ( BS2012SW024 ).",

year = "2013",

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doi = "10.1016/j.carbpol.2013.01.091",

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AU - Kong, Ming

AU - Park, Hyunjin

AU - Feng, Chao

AU - Hou, Lin

AU - Cheng, Xiaojie

AU - Chen, Xiguang

N1 - Funding Information: This study is supported by grant from NSFC ( 31240007 and 81271727 ) and Shandong Youth Scientist Awards Foundation ( BS2012SW024 ).

PY - 2013/4/15

Y1 - 2013/4/15

N2 - To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-Assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.

AB - To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-Assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.

KW - Hyaluronic acid

KW - Niosome

KW - Transdermal

KW - Tumor therapy

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Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy

Abstract

Keywords

ASJC Scopus subject areas

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