Construction of spatiotemporal infant cortical surface atlas of rhesus macaque

Fan Wang, Chunfeng Lian, Jing Xia, Zhengwang Wu, Dingna Duan, Li Wang, Dinggang Shen, Gang Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

As a widely used animal model in MR imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. However, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. Building age matched atlases for this critical period is thus highly desirable yet still lacking. In this paper, we construct the first spatiotemporal (4D) cortical surface atlases for rhesus macaques from 2 weeks to 24 months, using 138 longitudinal MRI scans from 32 healthy rhesus monkeys. Specifically, we first perform intra-subject cortical surface registration to obtain within-subject mean cortical surfaces. Then, we perform inter-subject registration of within-subject mean surfaces to obtain unbiased and longitudinally-consistent 4D cortical surface atlases. Based on our 4D rhesus monkey atlases, we further chart the first developmental-trajectories-based parcellation maps using the local surface area and spectral clustering algorithm. Our 4D macaque surface atlases and parcellation maps will greatly facilitate early brain development studies of macaques.

Original languageEnglish
Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PublisherIEEE Computer Society
Pages704-707
Number of pages4
ISBN (Electronic)9781538636367
DOIs
Publication statusPublished - 2018 May 23
Externally publishedYes
Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
Duration: 2018 Apr 42018 Apr 7

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2018-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
CountryUnited States
CityWashington
Period18/4/418/4/7

Keywords

  • Brain development
  • Cortical surface atlas
  • Monkey
  • Parcellation
  • Rhesus macaque

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Wang, F., Lian, C., Xia, J., Wu, Z., Duan, D., Wang, L., Shen, D., & Li, G. (2018). Construction of spatiotemporal infant cortical surface atlas of rhesus macaque. In 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018 (pp. 704-707). (Proceedings - International Symposium on Biomedical Imaging; Vol. 2018-April). IEEE Computer Society. https://doi.org/10.1109/ISBI.2018.8363671