Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application

Byeng Ha Ko, Subeen Yu, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

Abstract

A continuous flow reaction system was developed for the synthesis of 2,2,2-trichloroacetophenone derivatives. When aryl propiolic acids and water were mixed with trichloroisocyanuric acid in DMF at 5 °C, the 2,2,2-trichloroacetophenone derivatives were formed within 5 min with good yields. In addition, the resulting mixture was flowed to react with amines to give the corresponding benzamide. This flow reaction system provided higher yields within shorter times than the batch reaction system.

Original languageEnglish
Pages (from-to)991-994
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number11
DOIs
Publication statusPublished - 2018 Mar 14

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Amines
Derivatives
Water
benzamide
trichloroisocyanuric acid
propiolic acid

Keywords

  • Decarboxylative chlorination
  • Flow chemistry
  • Propiolic acid
  • Trichloroacetophenone
  • Trichloroisocyanuric acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application. / Ko, Byeng Ha; Yu, Subeen; Song, Kwang Ho; Lee, Sunwoo.

In: Tetrahedron Letters, Vol. 59, No. 11, 14.03.2018, p. 991-994.

Research output: Contribution to journalArticle

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