Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Jaehoon Choe, Hyosun Lee, Young Jun Kim, Sang Mi Lee, Kwang Ho Song

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Volume14
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

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Design of experiments
Condensation reactions
Purification
Flow rate
3-hydroxybutanal

Keywords

  • DOE
  • Endothermic
  • Micro module
  • Microreaction
  • Tubular mixer

ASJC Scopus subject areas

  • Engineering (miscellaneous)

Cite this

Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers. / Choe, Jaehoon; Lee, Hyosun; Kim, Young Jun; Lee, Sang Mi; Song, Kwang Ho.

In: Journal of Industrial and Engineering Chemistry, Vol. 14, No. 1, 01.01.2008, p. 66-70.

Research output: Contribution to journalArticle

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