Abstract
A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.
| Original language | English |
|---|---|
| Pages (from-to) | 66-70 |
| Number of pages | 5 |
| Journal | Journal of Industrial and Engineering Chemistry |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 Jan 1 |
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Keywords
- DOE
- Endothermic
- Micro module
- Microreaction
- Tubular mixer
ASJC Scopus subject areas
- Engineering (miscellaneous)
Cite this
Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers. / Choe, Jaehoon; Lee, Hyosun; Kim, Young Jun; Lee, Sang Mi; Song, Kwang Ho.
In: Journal of Industrial and Engineering Chemistry, Vol. 14, No. 1, 01.01.2008, p. 66-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers
AU - Choe, Jaehoon
AU - Lee, Hyosun
AU - Kim, Young Jun
AU - Lee, Sang Mi
AU - Song, Kwang Ho
PY - 2008/1/1
Y1 - 2008/1/1
N2 - A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.
AB - A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.
KW - DOE
KW - Endothermic
KW - Micro module
KW - Microreaction
KW - Tubular mixer
UR - http://www.scopus.com/inward/record.url?scp=37549016774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549016774&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2007.09.003
DO - 10.1016/j.jiec.2007.09.003
M3 - Article
VL - 14
SP - 66
EP - 70
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
IS - 1
ER -