Abstract
A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.
Original language | English |
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Pages (from-to) | 66-70 |
Number of pages | 5 |
Journal | Journal of Industrial and Engineering Chemistry |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 Jan |
Keywords
- DOE
- Endothermic
- Micro module
- Microreaction
- Tubular mixer
ASJC Scopus subject areas
- Chemical Engineering(all)