Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Jaehoon Choe; Hyosun Lee; Young Jun Kim; Sang Mi Lee; Kwang Ho Song

doi:10.1016/j.jiec.2007.09.003

Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Jaehoon Choe, Hyosun Lee, Young Jun Kim, Sang Mi Lee, Kwang Ho Song

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.

Original language	English
Pages (from-to)	66-70
Number of pages	5
Journal	Journal of Industrial and Engineering Chemistry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.jiec.2007.09.003
Publication status	Published - 2008 Jan

Keywords

DOE
Endothermic
Micro module
Microreaction
Tubular mixer

ASJC Scopus subject areas

Chemical Engineering(all)

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title = "Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers",

abstract = "A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.",

keywords = "DOE, Endothermic, Micro module, Microreaction, Tubular mixer",

author = "Jaehoon Choe and Hyosun Lee and Kim, {Young Jun} and Lee, {Sang Mi} and Song, {Kwang Ho}",

note = "Funding Information: This work has been supported by the Next Generation Novel Technology Development Program of the Ministry of Commerce, Industry and Energy (MOCIE) under the project title of “Development of Micro Optical and Thermofluidic Devices with High Functionality” and the Brain Korea 21 Project of the Ministry of Education & Human Resources Development. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2008",

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doi = "10.1016/j.jiec.2007.09.003",

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AU - Choe, Jaehoon

AU - Lee, Hyosun

AU - Kim, Young Jun

AU - Lee, Sang Mi

AU - Song, Kwang Ho

N1 - Funding Information: This work has been supported by the Next Generation Novel Technology Development Program of the Ministry of Commerce, Industry and Energy (MOCIE) under the project title of “Development of Micro Optical and Thermofluidic Devices with High Functionality” and the Brain Korea 21 Project of the Ministry of Education & Human Resources Development. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2008/1

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N2 - A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.

AB - A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.

KW - DOE

KW - Endothermic

KW - Micro module

KW - Microreaction

KW - Tubular mixer

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SN - 1226-086X

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Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Abstract

Keywords

ASJC Scopus subject areas

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