Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Jaehoon Choe; Hyosun Lee; Young Jun Kim; Sang Mi Lee; Kwang Ho Song

doi:10.1016/j.jiec.2007.09.003

Continuous production of 1-methyl-1-cyclopenten-3-one using a micro module combined with tubular mixers

Jaehoon Choe, Hyosun Lee, Young Jun Kim, Sang Mi Lee, Kwang Ho Song

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.

Original language	English
Pages (from-to)	66-70
Number of pages	5
Journal	Journal of Industrial and Engineering Chemistry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.jiec.2007.09.003
Publication status	Published - 2008 Jan

Keywords

DOE
Endothermic
Micro module
Microreaction
Tubular mixer

ASJC Scopus subject areas

Chemical Engineering(all)

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10.1016/j.jiec.2007.09.003

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abstract = "A high pressure microreaction system was applied to synthesize 1-methyl-1-cyclopenten-3-one. Design of experiment was used to identify the most dominant factors and the interactions from the microreaction system of an intramolecular aldol condensation reaction of 2,6-hexanedione. The response surface methodology coupled with Box-Behnken design was applied to obtain the optimum process conditions. The feed flow rates or residence time were identified as significant variables of this microreaction system. 1-methyl-1-cyclopenten-3-one was isolated in 60% yield after purification with 99.9% purity within the optimum operation ranges determined by design of experiment method.",

keywords = "DOE, Endothermic, Micro module, Microreaction, Tubular mixer",

author = "Jaehoon Choe and Hyosun Lee and Kim, {Young Jun} and Lee, {Sang Mi} and Song, {Kwang Ho}",

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AU - Lee, Sang Mi

AU - Song, Kwang Ho

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