Continuous production of neo-fructooligosaccharides by immobilization of whole cells of Penicillium citrinum

Man Chul Park, Jung Soo Lim, Jin Chul Kim, Seung Won Park, Seung Wook Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)


To produce neo-fructooligosaccharides (neo-FOSs) in a 500 ml continuous packed-bed reactor using whole cell immobilization of Penicillium citrinum KCCM 11663, the optimum reaction conditions were 50°C, pH 6 with 600 g sucrose l-1 being fed as substrate at 1.3 ml min-1. Under these conditions, the maximum neo-FOSs production was 49 g l-1. In a packed-bed reactor, continuous production of neo-FOSs was possible for 50 d indicating a potential for industrial production.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalBiotechnology Letters
Issue number2
Publication statusPublished - 2005 Jan 1



  • Cell immobilization
  • Continuous production
  • Neo-fructooligosaccharides
  • Packed-bed reactor
  • Penicillium citrinum

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

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