Abstract
In-line static mixer technology was employed in a continuous synthesis of a pharmaceutical intermediate of new quinolone antibiotics. The reaction of interest is the protection of amine with t-Boc, and it is characterized by a fast rate and relatively high exothermicity. The heat generated from the reaction can alter the reaction pathway or destroy the structure of the products. Reaction kinetics were derived from a series of batch measurements of heat flows using an RC1 reaction calorimeter. Results showed that the heat generated from the reaction initiated a mechanism for byproduct formation, and efficient mixing and heat removal with the static mixer led to reduced byproduct formation and promoted a high yield. On the basis of the reaction kinetics, a simple plug-flow reactor model was developed for this system.
Original language | English |
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Pages (from-to) | 187-190 |
Number of pages | 4 |
Journal | Organic Process Research and Development |
Volume | 7 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2003 Mar |
Externally published | Yes |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry