Abstract
In-line static mixer technology was employed in a continuous synthesis of a pharmaceutical intermediate of new quinolone antibiotics. The reaction of interest is the protection of amine with t-Boc, and it is characterized by a fast rate and relatively high exothermicity. The heat generated from the reaction can alter the reaction pathway or destroy the structure of the products. Reaction kinetics were derived from a series of batch measurements of heat flows using an RC1 reaction calorimeter. Results showed that the heat generated from the reaction initiated a mechanism for byproduct formation, and efficient mixing and heat removal with the static mixer led to reduced byproduct formation and promoted a high yield. On the basis of the reaction kinetics, a simple plug-flow reactor model was developed for this system.
| Original language | English |
|---|---|
| Pages (from-to) | 187-190 |
| Number of pages | 4 |
| Journal | Organic Process Research and Development |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 Mar 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
Cite this
Continuous synthesis of an intermediate of quinolone antibiotic drug using static mixers. / Choe, Jaehoon; Kim, Yeongdae; Song, Kwang Ho.
In: Organic Process Research and Development, Vol. 7, No. 2, 01.03.2003, p. 187-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Continuous synthesis of an intermediate of quinolone antibiotic drug using static mixers
AU - Choe, Jaehoon
AU - Kim, Yeongdae
AU - Song, Kwang Ho
PY - 2003/3/1
Y1 - 2003/3/1
N2 - In-line static mixer technology was employed in a continuous synthesis of a pharmaceutical intermediate of new quinolone antibiotics. The reaction of interest is the protection of amine with t-Boc, and it is characterized by a fast rate and relatively high exothermicity. The heat generated from the reaction can alter the reaction pathway or destroy the structure of the products. Reaction kinetics were derived from a series of batch measurements of heat flows using an RC1 reaction calorimeter. Results showed that the heat generated from the reaction initiated a mechanism for byproduct formation, and efficient mixing and heat removal with the static mixer led to reduced byproduct formation and promoted a high yield. On the basis of the reaction kinetics, a simple plug-flow reactor model was developed for this system.
AB - In-line static mixer technology was employed in a continuous synthesis of a pharmaceutical intermediate of new quinolone antibiotics. The reaction of interest is the protection of amine with t-Boc, and it is characterized by a fast rate and relatively high exothermicity. The heat generated from the reaction can alter the reaction pathway or destroy the structure of the products. Reaction kinetics were derived from a series of batch measurements of heat flows using an RC1 reaction calorimeter. Results showed that the heat generated from the reaction initiated a mechanism for byproduct formation, and efficient mixing and heat removal with the static mixer led to reduced byproduct formation and promoted a high yield. On the basis of the reaction kinetics, a simple plug-flow reactor model was developed for this system.
UR - http://www.scopus.com/inward/record.url?scp=0037358078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037358078&partnerID=8YFLogxK
U2 - 10.1021/op025561k
DO - 10.1021/op025561k
M3 - Article
AN - SCOPUS:0037358078
VL - 7
SP - 187
EP - 190
JO - Organic Process Research and Development
JF - Organic Process Research and Development
SN - 1083-6160
IS - 2
ER -