Contrast-enhanced FLAIR (Fluid-Attenuated Inversion Recovery) for evaluating mild traumatic brain injury

Soo Chin Kim, Sun Won Park, Inseon Ryoo, Seung Chai Jung, Tae Jin Yun, Seung Hong Choi, Ji Hoon Kim, Chul Ho Sohn

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate whether adding a contrast-enhanced fluid-attenuated inversion recovery (FLAIR) sequence to routine magnetic resonance imaging (MRI) can detect additional abnormalities in the brains of symptomatic patients with mild traumatic brain injury. Materials and Methods: Fifty-four patients with persistent symptoms following mild closed head injury were included in our retrospective study (M:F = 32:22, mean age: 59.8±16.4, age range: 26-84 years). All MRI examinations were obtained within 14 days after head trauma (mean: 3.2±4.1 days, range: 0.2-14 days). Two neuroradiologists recorded (1) the presence of traumatic brain lesions on MR images with and without contrast-enhanced FLAIR images and (2) the pattern and location of meningeal enhancement depicted on contrast-enhanced FLAIR images. The number of additional traumatic brain lesions diagnosed with contrast-enhanced FLAIR was recorded. Correlations between meningeal enhancement and clinical findings were also evaluated. Results: Traumatic brain lesions were detected on routine image sequences in 25 patients. Three additional cases of brain abnormality were detected with the contrast-enhanced FLAIR images. Meningeal enhancement was identified on contrast-enhanced FLAIR images in 9 cases while the other routine image sequences showed no findings of traumatic brain injury. Overall, the additional contrast-enhanced FLAIR images revealed more extensive abnormalities than routine imaging in 37 cases (p<0.001). In multivariate logistic regression analysis, subdural hematoma and posttraumatic loss of consciousness showed a significant association with meningeal enhancement on contrast-enhanced FLAIR images, with odds ratios 13.068 (95% confidence interval 2.037 to 83.852), and 15.487 (95% confidence interval 2.545 to 94.228), respectively. Conclusion: Meningeal enhancement on contrast-enhanced FLAIR images can help detect traumatic brain lesions as well as additional abnormalities not identified on routine unenhanced MRI. Therefore contrast-enhanced FLAIR MR imaging is recommended when a contrast MR study is indicated in a patient with a symptomatic prior closed mild head injury.

Original languageEnglish
Article numbere102229
JournalPLoS One
Volume9
Issue number7
DOIs
Publication statusPublished - 2014 Jul 16

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Brain Concussion
Brain
brain
Recovery
Fluids
Closed Head Injuries
lesions (animal)
Magnetic Resonance Imaging
Imaging techniques
Magnetic resonance
magnetic resonance imaging
Confidence Intervals
Sequence Inversion
Subdural Hematoma
Unconsciousness
confidence interval
Craniocerebral Trauma
fluids
image analysis
Retrospective Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Contrast-enhanced FLAIR (Fluid-Attenuated Inversion Recovery) for evaluating mild traumatic brain injury. / Kim, Soo Chin; Park, Sun Won; Ryoo, Inseon; Jung, Seung Chai; Yun, Tae Jin; Choi, Seung Hong; Kim, Ji Hoon; Sohn, Chul Ho.

In: PLoS One, Vol. 9, No. 7, e102229, 16.07.2014.

Research output: Contribution to journalArticle

Kim, Soo Chin ; Park, Sun Won ; Ryoo, Inseon ; Jung, Seung Chai ; Yun, Tae Jin ; Choi, Seung Hong ; Kim, Ji Hoon ; Sohn, Chul Ho. / Contrast-enhanced FLAIR (Fluid-Attenuated Inversion Recovery) for evaluating mild traumatic brain injury. In: PLoS One. 2014 ; Vol. 9, No. 7.
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AU - Choi, Seung Hong

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