Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: A multi-institutional study in 101487 patients

Joongyub Lee, Jeong Yeon Cho, Hak Jong Lee, Yong Yeon Jeong, Chan Kyo Kim, Byung Kwan Park, Deuk Jae Sung, Byung Chul Kang, Sung Il Jung, Eun Ju Lee, Boem Ha Yi, Seong Jin Park, Jong Chul Kim, Dae Chul Jung, Chang Kyu Sung, Yongsoo Kim, Youngrae Lee, Sun Ho Kim, Seong Kuk Yoon, Byung Joo ParkSeung Hyup Kim

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea. Materials and Methods: Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT. Results: Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 ± 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment. Conclusion: Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalKorean Journal of Radiology
Volume15
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Korea
Tomography
Glomerular Filtration Rate
Diabetes Mellitus
Heart Failure
Kidney
Preventive Medicine
Gout
Electronic Health Records
Tertiary Care Centers
Prescriptions
Comorbidity
Creatinine
Demography
Hypertension
Incidence
Serum

Keywords

  • Contrast-enhanced computed tomography
  • Contrast-induced nephropathy
  • Prevalence
  • Risk factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea : A multi-institutional study in 101487 patients. / Lee, Joongyub; Cho, Jeong Yeon; Lee, Hak Jong; Jeong, Yong Yeon; Kim, Chan Kyo; Park, Byung Kwan; Sung, Deuk Jae; Kang, Byung Chul; Jung, Sung Il; Lee, Eun Ju; Yi, Boem Ha; Park, Seong Jin; Kim, Jong Chul; Jung, Dae Chul; Sung, Chang Kyu; Kim, Yongsoo; Lee, Youngrae; Kim, Sun Ho; Yoon, Seong Kuk; Park, Byung Joo; Kim, Seung Hyup.

In: Korean Journal of Radiology, Vol. 15, No. 4, 01.01.2014, p. 456-463.

Research output: Contribution to journalArticle

Lee, J, Cho, JY, Lee, HJ, Jeong, YY, Kim, CK, Park, BK, Sung, DJ, Kang, BC, Jung, SI, Lee, EJ, Yi, BH, Park, SJ, Kim, JC, Jung, DC, Sung, CK, Kim, Y, Lee, Y, Kim, SH, Yoon, SK, Park, BJ & Kim, SH 2014, 'Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: A multi-institutional study in 101487 patients', Korean Journal of Radiology, vol. 15, no. 4, pp. 456-463. https://doi.org/10.3348/kjr.2014.15.4.456
Lee, Joongyub ; Cho, Jeong Yeon ; Lee, Hak Jong ; Jeong, Yong Yeon ; Kim, Chan Kyo ; Park, Byung Kwan ; Sung, Deuk Jae ; Kang, Byung Chul ; Jung, Sung Il ; Lee, Eun Ju ; Yi, Boem Ha ; Park, Seong Jin ; Kim, Jong Chul ; Jung, Dae Chul ; Sung, Chang Kyu ; Kim, Yongsoo ; Lee, Youngrae ; Kim, Sun Ho ; Yoon, Seong Kuk ; Park, Byung Joo ; Kim, Seung Hyup. / Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea : A multi-institutional study in 101487 patients. In: Korean Journal of Radiology. 2014 ; Vol. 15, No. 4. pp. 456-463.
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abstract = "Objective: To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea. Materials and Methods: Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25{\%} increase in serum creatinine after CECT. Results: Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 ± 15.5 years; 25.1{\%} of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9{\%}, of hypertension 13.7{\%}, of gout 0.55{\%} and of heart failure was 1.7{\%}. Preventive measures were used in 40238 CECT examinations (28.6{\%}). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2{\%}) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment. Conclusion: Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.",
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T1 - Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea

T2 - A multi-institutional study in 101487 patients

AU - Lee, Joongyub

AU - Cho, Jeong Yeon

AU - Lee, Hak Jong

AU - Jeong, Yong Yeon

AU - Kim, Chan Kyo

AU - Park, Byung Kwan

AU - Sung, Deuk Jae

AU - Kang, Byung Chul

AU - Jung, Sung Il

AU - Lee, Eun Ju

AU - Yi, Boem Ha

AU - Park, Seong Jin

AU - Kim, Jong Chul

AU - Jung, Dae Chul

AU - Sung, Chang Kyu

AU - Kim, Yongsoo

AU - Lee, Youngrae

AU - Kim, Sun Ho

AU - Yoon, Seong Kuk

AU - Park, Byung Joo

AU - Kim, Seung Hyup

PY - 2014/1/1

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N2 - Objective: To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea. Materials and Methods: Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT. Results: Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 ± 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment. Conclusion: Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.

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KW - Contrast-enhanced computed tomography

KW - Contrast-induced nephropathy

KW - Prevalence

KW - Risk factor

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