Contributions of the PPC to online control of visually guided reaching movements assessed with fMRI-Guided TMS

Alexandra Reichenbach, Jean Pierre Bresciani, Angelika Peer, Heinrich Bulthoff, Axel Thielscher

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The posterior parietal cortex (PPC) plays an important role in controlling voluntary movements by continuously integrating sensory information about body state and the environment. We tested which subregions of the PPC contribute to the processing of target- and body-related visual information while reaching for an object, using a reaching paradigm with 2 types of visual perturbation: displacement of the visual target and displacement of the visual feedback about the hand position. Initially, functional magnetic resonance imaging (fMRI) was used to localize putative target areas involved in online corrections of movements in response to perturbations. The causal contribution of these areas to online correction was tested in subsequent neuronavigated transcranial magnetic stimulation (TMS) experiments. Robust TMS effects occurred at distinct anatomical sites along the anterior intraparietal sulcus (aIPS) and the anterior part of the supramarginal gyrus for both perturbations. TMS over neighboring sites did not affect online control. Our results support the hypothesis that the aIPS is more generally involved in visually guided control of movements, independent of body effectors and nature of the visual information. Furthermore, they suggest that the human network of PPC subregions controlling goal-directed visuomotor processes extends more inferiorly than previously thought. Our results also point toward a good spatial specificity of the TMS effects.

Original languageEnglish
Pages (from-to)1602-1612
Number of pages11
JournalCerebral Cortex
Volume21
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

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Parietal Lobe
Transcranial Magnetic Stimulation
Magnetic Resonance Imaging
Sensory Feedback
Hand

Keywords

  • functional magnetic resonance imaging localizer
  • motor control
  • online responses
  • posterior parietal cortex
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Contributions of the PPC to online control of visually guided reaching movements assessed with fMRI-Guided TMS. / Reichenbach, Alexandra; Bresciani, Jean Pierre; Peer, Angelika; Bulthoff, Heinrich; Thielscher, Axel.

In: Cerebral Cortex, Vol. 21, No. 7, 01.07.2011, p. 1602-1612.

Research output: Contribution to journalArticle

Reichenbach, Alexandra ; Bresciani, Jean Pierre ; Peer, Angelika ; Bulthoff, Heinrich ; Thielscher, Axel. / Contributions of the PPC to online control of visually guided reaching movements assessed with fMRI-Guided TMS. In: Cerebral Cortex. 2011 ; Vol. 21, No. 7. pp. 1602-1612.
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