Contributors of the severity of airflow limitation in COPD patients

Yoonki Hong, Eun Jin Chae, Joon Beom Seo, Ji Hyun Lee, Eun Kyung Kim, Young Kyung Lee, Tae Hyung Kim, Woo Jin Kim, Jin Hwa Lee, Sang Min Lee, Sang Yeub Lee, Seong Yong Lim, Tae Rim Shin, Ho II Yoon, Seung Soo Sheen, Seung Won Ra, Jae Seung Lee, Jin Won Huh, Sang Do Lee, Yeon Mok Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Although airway obstruction in chronic obstructive pulmonary disease (COPD) is due to pathologic processes in both the airways and the lung parenchyma, the contribution of these processes, as well as other factors, have not yet been evaluated quantitatively. We therefore quantitatively evaluated the factors contributing to airflow limitation in patients with COPD. Methods: The 213 COPD patients were aged >45 years, had smoked >10 pack-years of cigarettes, and had a post-bronchodilator forced expiratory volume in one second (FEV 1)/forced vital capacity (FVC) <0.7. All patients were evaluated by medical interviews, physical examination, spirometry, bronchodilator reversibility tests, lung volume, and 6-minute walk tests. In addition, volumetric computed tomography (CT) was performed to evaluate airway wall thickness, emphysema severity, and mean lung density ratio at full expiration and inspiration. Multiple linear regression analysis was performed to identify the variables independently associated with FEV 1 - the index of the severity of airflow limitation. Results: Multiple linear regression analysis showed that CT measurements of mean lung density ratio (standardized coefficient β= -0.46; p<0.001), emphysema severity (volume fraction of the lung less than -950 HU at full inspiration; β= -0.24; p<0.001), and airway wall thickness (mean wall area %; β= -0.19, p=0.001), as well as current smoking status (β = -0.14; p=0.009) were independent contributors to FEV 1. Conclusion: Mean lung density ratio, emphysema severity, and airway wall thickness evaluated by volumetric CT and smoking status could independently contribute to the severity of airflow limitation in patients with COPD. Copyright

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume72
Issue number1
DOIs
Publication statusPublished - 2012 Jan 30

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Chronic Obstructive Pulmonary Disease
Lung
Emphysema
Cone-Beam Computed Tomography
Bronchodilator Agents
Linear Models
Smoking
Regression Analysis
Spirometry
Vital Capacity
Forced Expiratory Volume
Airway Obstruction
Pathologic Processes
Tobacco Products
Physical Examination
Tomography
Interviews

Keywords

  • Forced expiratory volumes
  • Pulmonary disease, chronic obstructive
  • Tomography, X-ray computed

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Hong, Y., Chae, E. J., Seo, J. B., Lee, J. H., Kim, E. K., Lee, Y. K., ... Oh, Y. M. (2012). Contributors of the severity of airflow limitation in COPD patients. Tuberculosis and Respiratory Diseases, 72(1), 8-14. https://doi.org/10.4046/trd.2012.72.1.8

Contributors of the severity of airflow limitation in COPD patients. / Hong, Yoonki; Chae, Eun Jin; Seo, Joon Beom; Lee, Ji Hyun; Kim, Eun Kyung; Lee, Young Kyung; Kim, Tae Hyung; Kim, Woo Jin; Lee, Jin Hwa; Lee, Sang Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho II; Sheen, Seung Soo; Ra, Seung Won; Lee, Jae Seung; Huh, Jin Won; Lee, Sang Do; Oh, Yeon Mok.

In: Tuberculosis and Respiratory Diseases, Vol. 72, No. 1, 30.01.2012, p. 8-14.

Research output: Contribution to journalArticle

Hong, Y, Chae, EJ, Seo, JB, Lee, JH, Kim, EK, Lee, YK, Kim, TH, Kim, WJ, Lee, JH, Lee, SM, Lee, SY, Lim, SY, Shin, TR, Yoon, HII, Sheen, SS, Ra, SW, Lee, JS, Huh, JW, Lee, SD & Oh, YM 2012, 'Contributors of the severity of airflow limitation in COPD patients', Tuberculosis and Respiratory Diseases, vol. 72, no. 1, pp. 8-14. https://doi.org/10.4046/trd.2012.72.1.8
Hong, Yoonki ; Chae, Eun Jin ; Seo, Joon Beom ; Lee, Ji Hyun ; Kim, Eun Kyung ; Lee, Young Kyung ; Kim, Tae Hyung ; Kim, Woo Jin ; Lee, Jin Hwa ; Lee, Sang Min ; Lee, Sang Yeub ; Lim, Seong Yong ; Shin, Tae Rim ; Yoon, Ho II ; Sheen, Seung Soo ; Ra, Seung Won ; Lee, Jae Seung ; Huh, Jin Won ; Lee, Sang Do ; Oh, Yeon Mok. / Contributors of the severity of airflow limitation in COPD patients. In: Tuberculosis and Respiratory Diseases. 2012 ; Vol. 72, No. 1. pp. 8-14.
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AU - Chae, Eun Jin

AU - Seo, Joon Beom

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AU - Kim, Eun Kyung

AU - Lee, Young Kyung

AU - Kim, Tae Hyung

AU - Kim, Woo Jin

AU - Lee, Jin Hwa

AU - Lee, Sang Min

AU - Lee, Sang Yeub

AU - Lim, Seong Yong

AU - Shin, Tae Rim

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AU - Sheen, Seung Soo

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N2 - Background: Although airway obstruction in chronic obstructive pulmonary disease (COPD) is due to pathologic processes in both the airways and the lung parenchyma, the contribution of these processes, as well as other factors, have not yet been evaluated quantitatively. We therefore quantitatively evaluated the factors contributing to airflow limitation in patients with COPD. Methods: The 213 COPD patients were aged >45 years, had smoked >10 pack-years of cigarettes, and had a post-bronchodilator forced expiratory volume in one second (FEV 1)/forced vital capacity (FVC) <0.7. All patients were evaluated by medical interviews, physical examination, spirometry, bronchodilator reversibility tests, lung volume, and 6-minute walk tests. In addition, volumetric computed tomography (CT) was performed to evaluate airway wall thickness, emphysema severity, and mean lung density ratio at full expiration and inspiration. Multiple linear regression analysis was performed to identify the variables independently associated with FEV 1 - the index of the severity of airflow limitation. Results: Multiple linear regression analysis showed that CT measurements of mean lung density ratio (standardized coefficient β= -0.46; p<0.001), emphysema severity (volume fraction of the lung less than -950 HU at full inspiration; β= -0.24; p<0.001), and airway wall thickness (mean wall area %; β= -0.19, p=0.001), as well as current smoking status (β = -0.14; p=0.009) were independent contributors to FEV 1. Conclusion: Mean lung density ratio, emphysema severity, and airway wall thickness evaluated by volumetric CT and smoking status could independently contribute to the severity of airflow limitation in patients with COPD. Copyright

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