Abstract
This study compared the ability of the Zeus® multifunctional anaesthesia system to control haemodynamic response to surgical stimulation in semi closed (SCA) or closed circuit anaesthesia (CCA) modes. Fifty patients undergoing gynaecological surgery were randomly assigned to SCA or CCA. Anaesthesia was induced with 2 mg propofol and 0.9 mg/kg rocuronium, intravenously, and maintained using sevoflurane (minimum alveolar concentration [MAC], 1.0) using 2 1/min oxygen plus 2 l/min nitrous oxide (SCA 4 l/min group) or 50% oxygen plus 50% nitrous oxide (CCA group). An increase in mean arterial pressure (MAP) > 20% above baseline in response to surgical stimulation provoked a stepwise increase in sevoflurane (1.3 MAC and then 1.6 MAC), followed by fentanyl 1 μg/kg intravenously (rescue drug). The time required for MAP to return to within 10% of baseline was significantly shorter in the CCA group (6.4 ± 3.6 min) compared with the SCA 4 l/min group (10.2 ± 6.0 min). The percentage of patients requiring fentanyl was significantly greater in the SCA 4 l/min group than in the CCA group. In conclusion, CCA controlled acute haemodynamic responses to surgical stimuli more successfully and rapidly than SCA 4 l/min, using a multifunctional anaesthesia machine.
| Original language | English |
|---|---|
| Pages (from-to) | 1637-1644 |
| Number of pages | 8 |
| Journal | Journal of International Medical Research |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
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Keywords
- Anaesthesia
- Closed circuit
- Haemodynamic control
- Semi-closed circuit
- Sevoflurane
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Biochemistry, medical
Cite this
Control of the haemodynamic response to surgical stimuli in semi-closed circuit or closed circuit anaesthesia using a multifunctional anaesthesia system. / Choi, Sung Uk; Shin, Hye Won; Jung, H. I.; Park, J. Y.; Yoon, Seung-Zhoo; Lee, Yoon Sook; Kim, Woon Young; Chang, S. H.
In: Journal of International Medical Research, Vol. 38, No. 5, 01.01.2010, p. 1637-1644.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Control of the haemodynamic response to surgical stimuli in semi-closed circuit or closed circuit anaesthesia using a multifunctional anaesthesia system
AU - Choi, Sung Uk
AU - Shin, Hye Won
AU - Jung, H. I.
AU - Park, J. Y.
AU - Yoon, Seung-Zhoo
AU - Lee, Yoon Sook
AU - Kim, Woon Young
AU - Chang, S. H.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - This study compared the ability of the Zeus® multifunctional anaesthesia system to control haemodynamic response to surgical stimulation in semi closed (SCA) or closed circuit anaesthesia (CCA) modes. Fifty patients undergoing gynaecological surgery were randomly assigned to SCA or CCA. Anaesthesia was induced with 2 mg propofol and 0.9 mg/kg rocuronium, intravenously, and maintained using sevoflurane (minimum alveolar concentration [MAC], 1.0) using 2 1/min oxygen plus 2 l/min nitrous oxide (SCA 4 l/min group) or 50% oxygen plus 50% nitrous oxide (CCA group). An increase in mean arterial pressure (MAP) > 20% above baseline in response to surgical stimulation provoked a stepwise increase in sevoflurane (1.3 MAC and then 1.6 MAC), followed by fentanyl 1 μg/kg intravenously (rescue drug). The time required for MAP to return to within 10% of baseline was significantly shorter in the CCA group (6.4 ± 3.6 min) compared with the SCA 4 l/min group (10.2 ± 6.0 min). The percentage of patients requiring fentanyl was significantly greater in the SCA 4 l/min group than in the CCA group. In conclusion, CCA controlled acute haemodynamic responses to surgical stimuli more successfully and rapidly than SCA 4 l/min, using a multifunctional anaesthesia machine.
AB - This study compared the ability of the Zeus® multifunctional anaesthesia system to control haemodynamic response to surgical stimulation in semi closed (SCA) or closed circuit anaesthesia (CCA) modes. Fifty patients undergoing gynaecological surgery were randomly assigned to SCA or CCA. Anaesthesia was induced with 2 mg propofol and 0.9 mg/kg rocuronium, intravenously, and maintained using sevoflurane (minimum alveolar concentration [MAC], 1.0) using 2 1/min oxygen plus 2 l/min nitrous oxide (SCA 4 l/min group) or 50% oxygen plus 50% nitrous oxide (CCA group). An increase in mean arterial pressure (MAP) > 20% above baseline in response to surgical stimulation provoked a stepwise increase in sevoflurane (1.3 MAC and then 1.6 MAC), followed by fentanyl 1 μg/kg intravenously (rescue drug). The time required for MAP to return to within 10% of baseline was significantly shorter in the CCA group (6.4 ± 3.6 min) compared with the SCA 4 l/min group (10.2 ± 6.0 min). The percentage of patients requiring fentanyl was significantly greater in the SCA 4 l/min group than in the CCA group. In conclusion, CCA controlled acute haemodynamic responses to surgical stimuli more successfully and rapidly than SCA 4 l/min, using a multifunctional anaesthesia machine.
KW - Anaesthesia
KW - Closed circuit
KW - Haemodynamic control
KW - Semi-closed circuit
KW - Sevoflurane
UR - http://www.scopus.com/inward/record.url?scp=78449278263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78449278263&partnerID=8YFLogxK
U2 - 10.1177/147323001003800508
DO - 10.1177/147323001003800508
M3 - Article
C2 - 21309477
AN - SCOPUS:78449278263
VL - 38
SP - 1637
EP - 1644
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 5
ER -