Control over micro-fluidity of liposomal membranes by hybridizing metal nanoparticles

Sung Hee Park, Seong Geun Oh, Kyung Do Suh, Sang Hoon Han, Dong June Chung, Ji Young Mun, Sung Sik Han, Jin Woong Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study introduces a facile method to hybridize metal nanoparticles with lipid vesicles, which allows us to control over their membrane micro-fluidity. We have fabricated these hybrid liposomes by directly hybridizing metal nanoparticles with lipid bilayers solely consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC). For this, we have used the dehydration and rehydration method. Characterizing their morphology and micro-fluidity, in which we have used electron microscopy and fluorescence anisotropy spectroscopy, enables us to demonstrate that metal nanoparticles with different surface properties create interactions with either phosphorus end groups or hydrophobic tails of DPPC, thereby resulting in decrease in micro-fluidity of the assembled lipid membranes, especially for the hydrophobic layers. Our approach to hybridize metal nanoparticles in between lipid layers offers a flexible means that allows us to obtain a liposome system with more controllable membrane properties.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume70
Issue number1
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Metal Nanoparticles
Membrane Fluidity
Fluidity
Metal nanoparticles
lipids
membranes
Membranes
nanoparticles
Liposomes
Phosphatidylcholines
metals
Lipids
Lipid bilayers
Fluorescence Polarization
Surface Properties
Fluid Therapy
Fluorescence Spectrometry
Lipid Bilayers
Membrane Lipids
Dehydration

Keywords

  • Hydrophobic layers
  • Interactions
  • Lipid membranes
  • Metal nanoparticles
  • Micro-fluidity

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Park, S. H., Oh, S. G., Suh, K. D., Han, S. H., Chung, D. J., Mun, J. Y., ... Kim, J. W. (2009). Control over micro-fluidity of liposomal membranes by hybridizing metal nanoparticles. Colloids and Surfaces B: Biointerfaces, 70(1), 108-113. https://doi.org/10.1016/j.colsurfb.2008.12.024

Control over micro-fluidity of liposomal membranes by hybridizing metal nanoparticles. / Park, Sung Hee; Oh, Seong Geun; Suh, Kyung Do; Han, Sang Hoon; Chung, Dong June; Mun, Ji Young; Han, Sung Sik; Kim, Jin Woong.

In: Colloids and Surfaces B: Biointerfaces, Vol. 70, No. 1, 01.04.2009, p. 108-113.

Research output: Contribution to journalArticle

Park, Sung Hee ; Oh, Seong Geun ; Suh, Kyung Do ; Han, Sang Hoon ; Chung, Dong June ; Mun, Ji Young ; Han, Sung Sik ; Kim, Jin Woong. / Control over micro-fluidity of liposomal membranes by hybridizing metal nanoparticles. In: Colloids and Surfaces B: Biointerfaces. 2009 ; Vol. 70, No. 1. pp. 108-113.
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