Controlled magnetic nanofiber hydrogels by clustering ferritin

Min Kyoon Shin, Sun I. Kim, Seon Jeong Kim, Sang Yoon Park, Young Hoon Hyun, YoungPak Lee, Kyung Eun Lee, Sung Sik Han, Dong Pyo Jang, Young Bo Kim, Zang Hee Cho, Insuk So, Geoffrey M. Spinks

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We have fabricated biocompatible nanofiber hydrogels with diverse sizes of ferritin clusters according to the mixing temperature of solutions employing electrospinning. Poly(vinyl alcohol) (PVA) was used as a polymeric matrix for fabricating nanocomposites. By thermal means we controlled the interaction between the host PVA hydrogel and the protein shell on ferritin bionanoparticles to vary the size and concentration of ferritin clusters. The clustering of ferritin was based on the partial unfolding of a protein shell of ferritin. By studying the magnetic properties of the PVA/ferritin nanofibers according to the mixing temperature of the PVA/ferritin solutions, we confirmed that the clustering process of the ferritin was related to changes in the superparamagnetic properties and magnetic resonance imaging (MRI) contrast of the PVA/ferritin nanofibers. PVA/ferritin nanofiber hydrogels with diverse spatial distributions of ferritin nanoparticles are applicable as MPI-based noninvasive detectable cell culture scaffolds and as artificial muscles because of their improved superparamagnetic properties.

Original languageEnglish
Pages (from-to)12107-12111
Number of pages5
JournalLangmuir
Volume24
Issue number21
DOIs
Publication statusPublished - 2008 Nov 4

Fingerprint

Nanofibers
Hydrogels
Ferritins
Cluster Analysis
proteins
muscles
magnetic resonance
nanocomposites
spatial distribution
alcohols
magnetic properties
Proteins
nanoparticles
temperature
Electrospinning
Magnetic resonance
Scaffolds (biology)
matrices
Cell culture
Spatial distribution

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Shin, M. K., Kim, S. I., Kim, S. J., Park, S. Y., Hyun, Y. H., Lee, Y., ... Spinks, G. M. (2008). Controlled magnetic nanofiber hydrogels by clustering ferritin. Langmuir, 24(21), 12107-12111. https://doi.org/10.1021/la802155a

Controlled magnetic nanofiber hydrogels by clustering ferritin. / Shin, Min Kyoon; Kim, Sun I.; Kim, Seon Jeong; Park, Sang Yoon; Hyun, Young Hoon; Lee, YoungPak; Lee, Kyung Eun; Han, Sung Sik; Jang, Dong Pyo; Kim, Young Bo; Cho, Zang Hee; So, Insuk; Spinks, Geoffrey M.

In: Langmuir, Vol. 24, No. 21, 04.11.2008, p. 12107-12111.

Research output: Contribution to journalArticle

Shin, MK, Kim, SI, Kim, SJ, Park, SY, Hyun, YH, Lee, Y, Lee, KE, Han, SS, Jang, DP, Kim, YB, Cho, ZH, So, I & Spinks, GM 2008, 'Controlled magnetic nanofiber hydrogels by clustering ferritin', Langmuir, vol. 24, no. 21, pp. 12107-12111. https://doi.org/10.1021/la802155a
Shin MK, Kim SI, Kim SJ, Park SY, Hyun YH, Lee Y et al. Controlled magnetic nanofiber hydrogels by clustering ferritin. Langmuir. 2008 Nov 4;24(21):12107-12111. https://doi.org/10.1021/la802155a
Shin, Min Kyoon ; Kim, Sun I. ; Kim, Seon Jeong ; Park, Sang Yoon ; Hyun, Young Hoon ; Lee, YoungPak ; Lee, Kyung Eun ; Han, Sung Sik ; Jang, Dong Pyo ; Kim, Young Bo ; Cho, Zang Hee ; So, Insuk ; Spinks, Geoffrey M. / Controlled magnetic nanofiber hydrogels by clustering ferritin. In: Langmuir. 2008 ; Vol. 24, No. 21. pp. 12107-12111.
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