Abstract
In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.
| Original language | English |
|---|---|
| Pages (from-to) | 201-208 |
| Number of pages | 8 |
| Journal | Journal of Pharmaceutical Investigation |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
| Externally published | Yes |
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Keywords
- Extended release formulation
- Multi-layer formulation
- REQUIP PD
- Ropinirole hydrochloride
- Wet granulation
- Zero-order release
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Cite this
Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation. / Lee, Jung Hwan; Yang, Jeawon; Park, Jin Young; Lee, Cheon Jung; Jang, Na Keum; Shin, Jae Hoon; Lim, Dong-Kwon; Khang, Gilson.
In: Journal of Pharmaceutical Investigation, Vol. 45, No. 2, 01.01.2015, p. 201-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation
AU - Lee, Jung Hwan
AU - Yang, Jeawon
AU - Park, Jin Young
AU - Lee, Cheon Jung
AU - Jang, Na Keum
AU - Shin, Jae Hoon
AU - Lim, Dong-Kwon
AU - Khang, Gilson
PY - 2015/1/1
Y1 - 2015/1/1
N2 - In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.
AB - In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.
KW - Extended release formulation
KW - Multi-layer formulation
KW - REQUIP PD
KW - Ropinirole hydrochloride
KW - Wet granulation
KW - Zero-order release
UR - http://www.scopus.com/inward/record.url?scp=84925148470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925148470&partnerID=8YFLogxK
U2 - 10.1007/s40005-014-0166-8
DO - 10.1007/s40005-014-0166-8
M3 - Article
VL - 45
SP - 201
EP - 208
JO - Journal of Pharmaceutical Investigation
JF - Journal of Pharmaceutical Investigation
SN - 2093-5552
IS - 2
ER -