Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation

Jung Hwan Lee, Jeawon Yang, Jin Young Park, Cheon Jung Lee, Na Keum Jang, Jae Hoon Shin, Dong-Kwon Lim, Gilson Khang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalJournal of Pharmaceutical Investigation
Volume45
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Keywords

  • Extended release formulation
  • Multi-layer formulation
  • REQUIP PD
  • Ropinirole hydrochloride
  • Wet granulation
  • Zero-order release

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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