Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation

Jung Hwan Lee; Jeawon Yang; Jin Young Park; Cheon Jung Lee; Na Keum Jang; Jae Hoon Shin; Dong Kwon Lim; Gilson Khang

doi:10.1007/s40005-014-0166-8

Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation

Jung Hwan Lee, Jeawon Yang, Jin Young Park, Cheon Jung Lee, Na Keum Jang, Jae Hoon Shin, Dong Kwon Lim, Gilson Khang

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD^®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD^®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.

Original language	English
Pages (from-to)	201-208
Number of pages	8
Journal	Journal of Pharmaceutical Investigation
Volume	45
Issue number	2
DOIs	https://doi.org/10.1007/s40005-014-0166-8
Publication status	Published - 2015 Apr
Externally published	Yes

Keywords

Extended release formulation
Multi-layer formulation
REQUIP PD
Ropinirole hydrochloride
Wet granulation
Zero-order release

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.1007/s40005-014-0166-8

Cite this

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title = "Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation",

abstract = "In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD{\textregistered}, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD{\textregistered}. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.",

keywords = "Extended release formulation, Multi-layer formulation, REQUIP PD, Ropinirole hydrochloride, Wet granulation, Zero-order release",

author = "Lee, {Jung Hwan} and Jeawon Yang and Park, {Jin Young} and Lee, {Cheon Jung} and Jang, {Na Keum} and Shin, {Jae Hoon} and Lim, {Dong Kwon} and Gilson Khang",

note = "Funding Information: This article does not contain any studies with human and animal subjects performed by any of the authors. All authors (J. H. Lee, J. Y, J. Y. Park, C. J. Lee, N. K. Jang, J. H . Shin, D. K. Lim, G. Khang) declare that they have no conflict of interest. This work was supported by MIFAFF (112007-05-1-SB010) and MEST (NRF-2012M3A9C6050204). Publisher Copyright: {\textcopyright} 2015, The Korean Society of Pharmaceutical Sciences and Technology.",

year = "2015",

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doi = "10.1007/s40005-014-0166-8",

language = "English",

volume = "45",

pages = "201--208",

journal = "Journal of Pharmaceutical Investigation",

issn = "2093-5552",

publisher = "Springer Netherlands",

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T1 - Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation

AU - Lee, Jung Hwan

AU - Yang, Jeawon

AU - Park, Jin Young

AU - Lee, Cheon Jung

AU - Jang, Na Keum

AU - Shin, Jae Hoon

AU - Lim, Dong Kwon

AU - Khang, Gilson

N1 - Funding Information: This article does not contain any studies with human and animal subjects performed by any of the authors. All authors (J. H. Lee, J. Y, J. Y. Park, C. J. Lee, N. K. Jang, J. H . Shin, D. K. Lim, G. Khang) declare that they have no conflict of interest. This work was supported by MIFAFF (112007-05-1-SB010) and MEST (NRF-2012M3A9C6050204). Publisher Copyright: © 2015, The Korean Society of Pharmaceutical Sciences and Technology.

PY - 2015/4

Y1 - 2015/4

N2 - In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.

AB - In this paper, we report cost-effective and simply achievable extended release formulations of ropinirole hydrochloride (RP) by forming coating layers with well-known polymers. The upper and bottom coating layers were composed of one of gel-forming polymers such as PEG, PVP, and HPMC, respectively, designed to control drug release profile. The core tablet is prepared by wet granulation method with RP and HPMC (150 K). The multi-layer tablet showed much slower release behavior than that of commercially available once-diary formulation (REQUIP PD®, 4 mg, GSK) in the pH 1.2 conditions regardless of coated polymers, and zero order release profiles of RP were observed in the pH 6.8 dissolution conditions, which is nearly identical to dissolution profile of REQUIP PD®. These results indicate that the formation of multi-layer tablet is one of promising strategies for extended release formulation of RP, in addition, better bioavailability is expected due to minimized dissolution profiles of RP in low pH.

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KW - Multi-layer formulation

KW - REQUIP PD

KW - Ropinirole hydrochloride

KW - Wet granulation

KW - Zero-order release

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JF - Journal of Pharmaceutical Investigation

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Controlled release behavior and characterization of ropinirole hydrochloride using multi-layer formulation

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