Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core

Špela Zupančič, Sumit Sinha-Ray, Suman Sinha-Ray, Julijana Kristl, Alexander Yarin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Sustained controlled drug release is one of the prominent contributions for more successful treatment outcomes in the case of several diseases. However, the incorporation of hydrophilic drugs into nanofibers, a promising novel delivery system, and achieving a long-term sustained release still pose a challenging task. In this work we demonstrated a robust method of avoiding burst release of drugs and achieving a sustained drug release from 2 to 4 weeks using core-shell nanofibers with poly(methyl methacrylate) (PMMA) shell and monolithic poly(vinyl alcohol) (PVA) core or a novel type of core-shell nanofibers with blended (PVA and PMMA) core loaded with ciprofloxacin hydrochloride (CIP). It is also shown that, for core-shell nanofibers with monolithic core, drug release can be manipulated by varying flow rate of the core PVA solution, whereas for core-shell nanofibers with blended core, drug release can be manipulated by varying the ratios between PMMA and PVA in the core. During coaxial electrospinning, when the solvent from the core evaporates in concert with the solvent from the shell, the interconnected pores spanning the core and the shell are formed. The release process is found to be desorption-limited and agrees with the two-stage desorption model. Ciprofloxacin-loaded nanofiber mats developed in the present work could be potentially used as local drug delivery systems for treatment of several medical conditions, including periodontal disease and skin, bone, and joint infections.

Original languageEnglish
Pages (from-to)1393-1404
Number of pages12
JournalMolecular Pharmaceutics
Volume13
Issue number4
DOIs
Publication statusPublished - 2016 Apr 4

Fingerprint

Nanofibers
Ciprofloxacin
Polymethyl Methacrylate
Periodontal Diseases
Drug Delivery Systems
Joints
Alcohols
Drug Liberation
Bone and Bones
Skin
Infection
Pharmaceutical Preparations

Keywords

  • antibiotic
  • ciprofloxacin hydrochloride
  • coaxial electrospinning
  • core-shell nanofibers
  • phase separation
  • sustained drug release

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

Cite this

Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core. / Zupančič, Špela; Sinha-Ray, Sumit; Sinha-Ray, Suman; Kristl, Julijana; Yarin, Alexander.

In: Molecular Pharmaceutics, Vol. 13, No. 4, 04.04.2016, p. 1393-1404.

Research output: Contribution to journalArticle

Zupančič, Špela ; Sinha-Ray, Sumit ; Sinha-Ray, Suman ; Kristl, Julijana ; Yarin, Alexander. / Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core. In: Molecular Pharmaceutics. 2016 ; Vol. 13, No. 4. pp. 1393-1404.
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