Controlled release of macromolecules from electrical and chemical stimuli‐sensitive hydrogels

You Han Bae, Ick Chan Kwon, Chaul Min Pai, Sung Wan Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The controlled release of drugs from hydrogels has progressed from systems that merely swell in water, to novel hydrogels with specific chemical properties which respond to various stimuli to facilitate drug release. Specifically, electro‐erodible hydrogels are synthesized by polymer chain complexation and precipitation through hydrogen or ionic bonds. The surface of the solid polymer device is eroded or dissolved in response to an applied electric current. When a constant electric current is applied, zero‐order release of entrapped drug is achieved. However, if a step‐function current is applied, the drug can be released in an on‐off pattern. Concanavalin A microspheres, a protein gel, has been synthesized to release insulin in response to glucose concentrations. This microsphere gel has specific binding affinity for glucose and mannose. A synthesized glycosylated insulin was loaded on the microspheres and then released in response to glucose concentrations via a competitive binding exchange mechanism.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalMakromolekulare Chemie. Macromolecular Symposia
Volume70-71
Issue number1
DOIs
Publication statusPublished - 1993 May

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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