Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells

Jaemoon Yang, Jihye Choi, Doyeon Bang, Eunjung Kim, Eun Kyung Lim, Huiyul Park, Jin Suck Suh, Kwangyeol Lee, Kyung Hwa Yoo, Eun Kyung Kim, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number2
DOIs
Publication statusPublished - 2011 Jan 10

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Ablation
Cells
Nanoparticles
Infrared radiation
Infrared lasers
Laser beam effects
Polyaniline
Absorption spectra
Salts
Wavelength
Water
polyaniline

Keywords

  • cancer
  • nanoparticles
  • near-infrared light
  • photothermal agents
  • polymers

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. / Yang, Jaemoon; Choi, Jihye; Bang, Doyeon; Kim, Eunjung; Lim, Eun Kyung; Park, Huiyul; Suh, Jin Suck; Lee, Kwangyeol; Yoo, Kyung Hwa; Kim, Eun Kyung; Huh, Yong Min; Haam, Seungjoo.

In: Angewandte Chemie - International Edition, Vol. 50, No. 2, 10.01.2011, p. 441-444.

Research output: Contribution to journalArticle

Yang, J, Choi, J, Bang, D, Kim, E, Lim, EK, Park, H, Suh, JS, Lee, K, Yoo, KH, Kim, EK, Huh, YM & Haam, S 2011, 'Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells', Angewandte Chemie - International Edition, vol. 50, no. 2, pp. 441-444. https://doi.org/10.1002/anie.201005075
Yang, Jaemoon ; Choi, Jihye ; Bang, Doyeon ; Kim, Eunjung ; Lim, Eun Kyung ; Park, Huiyul ; Suh, Jin Suck ; Lee, Kwangyeol ; Yoo, Kyung Hwa ; Kim, Eun Kyung ; Huh, Yong Min ; Haam, Seungjoo. / Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 2. pp. 441-444.
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