Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells

Jaemoon Yang, Jihye Choi, Doyeon Bang, Eunjung Kim, Eun Kyung Lim, Huiyul Park, Jin Suck Suh, Kwangyeol Lee, Kyung Hwa Yoo, Eun Kyung Kim, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number2
DOIs
Publication statusPublished - 2011 Jan 10

Keywords

  • cancer
  • nanoparticles
  • near-infrared light
  • photothermal agents
  • polymers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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    Yang, J., Choi, J., Bang, D., Kim, E., Lim, E. K., Park, H., Suh, J. S., Lee, K., Yoo, K. H., Kim, E. K., Huh, Y. M., & Haam, S. (2011). Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. Angewandte Chemie - International Edition, 50(2), 441-444. https://doi.org/10.1002/anie.201005075