Coordinative and limb-specific control of bimanual movements in patients with Parkinson's disease and cerebellar degeneration

Yong Gwan Song, Kyoung Seok Yoo, Kun Woo Park, Jin Hoon Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study examined the effects of basal ganglia and cerebellar pathology on bimanual coordination using patients with Parkinson's disease (PD) and cerebellar dysfunction (CD). Twenty patients with idiopathic PD (10 untreated early and 10 advanced PD), 10 patients with cerebellar degeneration, and 11 normal subjects were instructed to perform in-phase and anti-phase bimanual coordination movements. The results indicated that while the quality of coordinated bimanual movements in untreated early PD and CD patients was not significantly different from that of normal controls, advanced PD patients exhibited reduced synchronized coordination during the faster anti-phase mode. This suggests that the observed bimanual coordination abnormalities in PD are not an early sign of the pathophysiology of the disease, and cerebellar degeneration may have minimal consequences on synchronized coordination between the limbs. In terms of the parameterization of individual limb movements, CD patients showed a tendency for hypermetric impairments with more irregular movements, while PD patients exhibited relatively slower limb movements and lower amplitudes than normal controls. Overall, the current data provide evidence of the specific functions of different neural structures involved in the pathological process of PD and CD on bimanual coordination.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalNeuroscience Letters
Volume482
Issue number2
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • Basal ganglia
  • Cerebellar ataxia
  • Coordination
  • Harmonicity
  • Parameterization

ASJC Scopus subject areas

  • Neuroscience(all)

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