Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin

Keun Sang Oh, Yun Sik Um, Jin Ho Lee, Sun Hang Cho, Kyung Eun Lee, Sung Sik Han, Dongmin Kim, Soon Hong Yuk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freezedrying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.

Original languageEnglish
Pages (from-to)6967-6971
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

Fingerprint

Nanoparticles
Doxorubicin
delivery
drugs
Lecithin
nanoparticles
Lecithins
Drug Delivery Systems
Polyethylene oxides
Pharmaceutical Preparations
Lipids
Polypropylene oxides
Poloxamer
Trehalose
ethylene oxide
lipids
Block copolymers
propylene oxide
polypropylene
copolymers

Keywords

  • Core/Shell Nanoparticles with Drug-Loaded Lipid Cores
  • Doxorubicin
  • Lecithin
  • pH Sensitive Release of Anticancer Drug
  • Pluronics

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Oh, K. S., Um, Y. S., Lee, J. H., Cho, S. H., Lee, K. E., Han, S. S., ... Yuk, S. H. (2010). Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin. Journal of Nanoscience and Nanotechnology, 10(10), 6967-6971. https://doi.org/10.1166/jnn.2010.2986

Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin. / Oh, Keun Sang; Um, Yun Sik; Lee, Jin Ho; Cho, Sun Hang; Lee, Kyung Eun; Han, Sung Sik; Kim, Dongmin; Yuk, Soon Hong.

In: Journal of Nanoscience and Nanotechnology, Vol. 10, No. 10, 01.10.2010, p. 6967-6971.

Research output: Contribution to journalArticle

Oh, KS, Um, YS, Lee, JH, Cho, SH, Lee, KE, Han, SS, Kim, D & Yuk, SH 2010, 'Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin', Journal of Nanoscience and Nanotechnology, vol. 10, no. 10, pp. 6967-6971. https://doi.org/10.1166/jnn.2010.2986
Oh, Keun Sang ; Um, Yun Sik ; Lee, Jin Ho ; Cho, Sun Hang ; Lee, Kyung Eun ; Han, Sung Sik ; Kim, Dongmin ; Yuk, Soon Hong. / Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin. In: Journal of Nanoscience and Nanotechnology. 2010 ; Vol. 10, No. 10. pp. 6967-6971.
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