Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin

Keun Sang Oh, Yun Sik Um, Jin Ho Lee, Sun Hang Cho, Kyung Eun Lee, Sung Sik Han, Dongmin Kim, Soon Hong Yuk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freezedrying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.

Original languageEnglish
Pages (from-to)6967-6971
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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Keywords

  • Core/Shell Nanoparticles with Drug-Loaded Lipid Cores
  • Doxorubicin
  • Lecithin
  • pH Sensitive Release of Anticancer Drug
  • Pluronics

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Oh, K. S., Um, Y. S., Lee, J. H., Cho, S. H., Lee, K. E., Han, S. S., Kim, D., & Yuk, S. H. (2010). Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin. Journal of Nanoscience and Nanotechnology, 10(10), 6967-6971. https://doi.org/10.1166/jnn.2010.2986