Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin

Keun Sang Oh, Yun Sik Um, Jin Ho Lee, Sun Hang Cho, Kyung Eun Lee, Sung Sik Han, Dongmin Kim, Soon Hong Yuk

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freezedrying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.

Original languageEnglish
Pages (from-to)6967-6971
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number10
DOIs
Publication statusPublished - 2010 Oct

Keywords

  • Core/Shell Nanoparticles with Drug-Loaded Lipid Cores
  • Doxorubicin
  • Lecithin
  • Pluronics
  • pH Sensitive Release of Anticancer Drug

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

Fingerprint

Dive into the research topics of 'Core/Shell nanoparticles for ph-sensitive delivery of doxorubicin'. Together they form a unique fingerprint.

Cite this