Core/shell nanoparticles with lecithin lipid cores for protein delivery

Keun Sang Oh, Sung Kyun Han, Hyun Suk Lee, Hyoung Mo Koo, Ree Sun Kim, Kyung Eun Lee, Sung Sik Han, Sun Hang Cho, Soon Hong Yuk

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Core/shell nanoparticles with lipid core, were prepared and characterized as a sustained delivery system for protein. The lipid core is composed of protein-loaded lecithin and the polymeric shell is composed of Pluronics (poly-(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of protein-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/ shell nanoparticles. Cryo-TEM (transmittance electron microscopy) and a particle size analyzer were used to observe the formation of stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a protein drug carrier, lysozyme and vascular endothelial growth factor (VEGF) were loaded into the core/shell nanoparticles by electrostatic interaction, and the drug release pattern was observed by manipulating the polymeric shell.

Original languageEnglish
Pages (from-to)2362-2367
Number of pages6
JournalBiomacromolecules
Volume7
Issue number8
DOIs
Publication statusPublished - 2006 Aug 1

Fingerprint

Lecithin
Lecithins
Nanoparticles
Lipids
Proteins
Polyethylene oxides
Polypropylene oxides
Poloxamer
Trehalose
Drug Carriers
Freeze Drying
Muramidase
Coulomb interactions
Static Electricity
Particle Size
Electron microscopy
Vascular Endothelial Growth Factor A
Block copolymers
Electron Microscopy
Drying

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Oh, K. S., Han, S. K., Lee, H. S., Koo, H. M., Kim, R. S., Lee, K. E., ... Yuk, S. H. (2006). Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules, 7(8), 2362-2367. https://doi.org/10.1021/bm060362k

Core/shell nanoparticles with lecithin lipid cores for protein delivery. / Oh, Keun Sang; Han, Sung Kyun; Lee, Hyun Suk; Koo, Hyoung Mo; Kim, Ree Sun; Lee, Kyung Eun; Han, Sung Sik; Cho, Sun Hang; Yuk, Soon Hong.

In: Biomacromolecules, Vol. 7, No. 8, 01.08.2006, p. 2362-2367.

Research output: Contribution to journalArticle

Oh, KS, Han, SK, Lee, HS, Koo, HM, Kim, RS, Lee, KE, Han, SS, Cho, SH & Yuk, SH 2006, 'Core/shell nanoparticles with lecithin lipid cores for protein delivery', Biomacromolecules, vol. 7, no. 8, pp. 2362-2367. https://doi.org/10.1021/bm060362k
Oh KS, Han SK, Lee HS, Koo HM, Kim RS, Lee KE et al. Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules. 2006 Aug 1;7(8):2362-2367. https://doi.org/10.1021/bm060362k
Oh, Keun Sang ; Han, Sung Kyun ; Lee, Hyun Suk ; Koo, Hyoung Mo ; Kim, Ree Sun ; Lee, Kyung Eun ; Han, Sung Sik ; Cho, Sun Hang ; Yuk, Soon Hong. / Core/shell nanoparticles with lecithin lipid cores for protein delivery. In: Biomacromolecules. 2006 ; Vol. 7, No. 8. pp. 2362-2367.
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