Core/shell nanoparticles with lecithin lipid cores for protein delivery

Keun Sang Oh, Sung Kyun Han, Hyun Suk Lee, Hyoung Mo Koo, Ree Sun Kim, Kyung Eun Lee, Sung Sik Han, Sun Hang Cho, Soon Hong Yuk

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48 Citations (Scopus)

Abstract

Core/shell nanoparticles with lipid core, were prepared and characterized as a sustained delivery system for protein. The lipid core is composed of protein-loaded lecithin and the polymeric shell is composed of Pluronics (poly-(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of protein-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/ shell nanoparticles. Cryo-TEM (transmittance electron microscopy) and a particle size analyzer were used to observe the formation of stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a protein drug carrier, lysozyme and vascular endothelial growth factor (VEGF) were loaded into the core/shell nanoparticles by electrostatic interaction, and the drug release pattern was observed by manipulating the polymeric shell.

Original languageEnglish
Pages (from-to)2362-2367
Number of pages6
JournalBiomacromolecules
Volume7
Issue number8
DOIs
Publication statusPublished - 2006 Aug 1

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ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Oh, K. S., Han, S. K., Lee, H. S., Koo, H. M., Kim, R. S., Lee, K. E., Han, S. S., Cho, S. H., & Yuk, S. H. (2006). Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules, 7(8), 2362-2367. https://doi.org/10.1021/bm060362k