Coronary Computed Tomography Angiography Predicts Guidewire Crossing and Success of Percutaneous Intervention for Chronic Total Occlusion

Cheol Woong Yu, Hyun Jong Lee, Jon Suh, Nae Hee Lee, Sang Min Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo Yong Hahn, Seung Hyuk Choi, Hyeon Cheol Gwon, Sang Hoon Lee, Yeon Hyeon Choe, Sung Mok Kim, Jin Ho Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background - We developed a model that predicts difficulty of percutaneous coronary intervention for coronary chronic total occlusion (CTO) using coronary computed tomographic angiography. Methods and Results - A total of 684 CTO lesions with preprocedural computed tomographic angiography were enrolled from 4 centers. Data were randomly divided into derivation and validation datasets at 2:1 ratio. The end point was successful guidewire crossing ≤30 minutes, which was met in 50%. The KCCT (Korean Multicenter CTO CT Registry) score was developed based on independent predictors identified by multivariable analysis, which were proximal blunt entry, proximal side branch, bending, occlusion length ≥15 mm, severe calcification, whole luminal calcification, reattempt, and ≥12 months or unknown duration of occlusion. The KCCT score was compared with the other prediction scores, including angiography-based J-CTO, PROGRESS-CTO, CL-score, and CT-based CT-RECTOR. The probability of guidewire crossing ≤30 minutes declined consistently from 100% to 0% according to the KCCT score (P<0.01, all). The KCCT score showed higher discriminative performance compared with the other scoring systems (c-statistics=0.78 versus 0.65-0.72, P<0.001, all). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of a KCCT score of <4 for guidewire crossing ≤30 minutes was 70%, 68%, 72%, 73%, and 70%, respectively. The KCCT score also showed consistent results with procedural success (P<0.05, all). These results could be reproduced in validation data set (P<0.05, all). Conclusions - KCCT scoring could predict successful guidewire crossing ≤30 minutes and also procedural success. KCCT scoring may enable noninvasive grading difficulty of CTO percutaneous coronary intervention.

Original languageEnglish
Article numbere005800
JournalCirculation: Cardiovascular Imaging
Volume10
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1
Externally publishedYes

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Angiography
Percutaneous Coronary Intervention
Coronary Occlusion
Registries
Sensitivity and Specificity
Computed Tomography Angiography
Datasets

Keywords

  • angiography
  • computed tomographic angiography
  • percutaneous coronary intervention
  • probability
  • sensitivity and specificity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Coronary Computed Tomography Angiography Predicts Guidewire Crossing and Success of Percutaneous Intervention for Chronic Total Occlusion. / Yu, Cheol Woong; Lee, Hyun Jong; Suh, Jon; Lee, Nae Hee; Park, Sang Min; Park, Taek Kyu; Yang, Jeong Hoon; Song, Young Bin; Hahn, Joo Yong; Choi, Seung Hyuk; Gwon, Hyeon Cheol; Lee, Sang Hoon; Choe, Yeon Hyeon; Kim, Sung Mok; Choi, Jin Ho.

In: Circulation: Cardiovascular Imaging, Vol. 10, No. 4, e005800, 01.04.2017.

Research output: Contribution to journalArticle

Yu, CW, Lee, HJ, Suh, J, Lee, NH, Park, SM, Park, TK, Yang, JH, Song, YB, Hahn, JY, Choi, SH, Gwon, HC, Lee, SH, Choe, YH, Kim, SM & Choi, JH 2017, 'Coronary Computed Tomography Angiography Predicts Guidewire Crossing and Success of Percutaneous Intervention for Chronic Total Occlusion', Circulation: Cardiovascular Imaging, vol. 10, no. 4, e005800. https://doi.org/10.1161/CIRCIMAGING.116.005800
Yu, Cheol Woong ; Lee, Hyun Jong ; Suh, Jon ; Lee, Nae Hee ; Park, Sang Min ; Park, Taek Kyu ; Yang, Jeong Hoon ; Song, Young Bin ; Hahn, Joo Yong ; Choi, Seung Hyuk ; Gwon, Hyeon Cheol ; Lee, Sang Hoon ; Choe, Yeon Hyeon ; Kim, Sung Mok ; Choi, Jin Ho. / Coronary Computed Tomography Angiography Predicts Guidewire Crossing and Success of Percutaneous Intervention for Chronic Total Occlusion. In: Circulation: Cardiovascular Imaging. 2017 ; Vol. 10, No. 4.
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abstract = "Background - We developed a model that predicts difficulty of percutaneous coronary intervention for coronary chronic total occlusion (CTO) using coronary computed tomographic angiography. Methods and Results - A total of 684 CTO lesions with preprocedural computed tomographic angiography were enrolled from 4 centers. Data were randomly divided into derivation and validation datasets at 2:1 ratio. The end point was successful guidewire crossing ≤30 minutes, which was met in 50{\%}. The KCCT (Korean Multicenter CTO CT Registry) score was developed based on independent predictors identified by multivariable analysis, which were proximal blunt entry, proximal side branch, bending, occlusion length ≥15 mm, severe calcification, whole luminal calcification, reattempt, and ≥12 months or unknown duration of occlusion. The KCCT score was compared with the other prediction scores, including angiography-based J-CTO, PROGRESS-CTO, CL-score, and CT-based CT-RECTOR. The probability of guidewire crossing ≤30 minutes declined consistently from 100{\%} to 0{\%} according to the KCCT score (P<0.01, all). The KCCT score showed higher discriminative performance compared with the other scoring systems (c-statistics=0.78 versus 0.65-0.72, P<0.001, all). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of a KCCT score of <4 for guidewire crossing ≤30 minutes was 70{\%}, 68{\%}, 72{\%}, 73{\%}, and 70{\%}, respectively. The KCCT score also showed consistent results with procedural success (P<0.05, all). These results could be reproduced in validation data set (P<0.05, all). Conclusions - KCCT scoring could predict successful guidewire crossing ≤30 minutes and also procedural success. KCCT scoring may enable noninvasive grading difficulty of CTO percutaneous coronary intervention.",
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AU - Lee, Hyun Jong

AU - Suh, Jon

AU - Lee, Nae Hee

AU - Park, Sang Min

AU - Park, Taek Kyu

AU - Yang, Jeong Hoon

AU - Song, Young Bin

AU - Hahn, Joo Yong

AU - Choi, Seung Hyuk

AU - Gwon, Hyeon Cheol

AU - Lee, Sang Hoon

AU - Choe, Yeon Hyeon

AU - Kim, Sung Mok

AU - Choi, Jin Ho

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N2 - Background - We developed a model that predicts difficulty of percutaneous coronary intervention for coronary chronic total occlusion (CTO) using coronary computed tomographic angiography. Methods and Results - A total of 684 CTO lesions with preprocedural computed tomographic angiography were enrolled from 4 centers. Data were randomly divided into derivation and validation datasets at 2:1 ratio. The end point was successful guidewire crossing ≤30 minutes, which was met in 50%. The KCCT (Korean Multicenter CTO CT Registry) score was developed based on independent predictors identified by multivariable analysis, which were proximal blunt entry, proximal side branch, bending, occlusion length ≥15 mm, severe calcification, whole luminal calcification, reattempt, and ≥12 months or unknown duration of occlusion. The KCCT score was compared with the other prediction scores, including angiography-based J-CTO, PROGRESS-CTO, CL-score, and CT-based CT-RECTOR. The probability of guidewire crossing ≤30 minutes declined consistently from 100% to 0% according to the KCCT score (P<0.01, all). The KCCT score showed higher discriminative performance compared with the other scoring systems (c-statistics=0.78 versus 0.65-0.72, P<0.001, all). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of a KCCT score of <4 for guidewire crossing ≤30 minutes was 70%, 68%, 72%, 73%, and 70%, respectively. The KCCT score also showed consistent results with procedural success (P<0.05, all). These results could be reproduced in validation data set (P<0.05, all). Conclusions - KCCT scoring could predict successful guidewire crossing ≤30 minutes and also procedural success. KCCT scoring may enable noninvasive grading difficulty of CTO percutaneous coronary intervention.

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KW - sensitivity and specificity

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