Coronary endothelial dysfunction associated with a depressive mood in patients with atypical angina but angiographically normal coronary artery

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Abstract

Background: Depression is a risk factor for the development of coronary heart disease but the relationship between coronary endothelial dysfunction and depression is not yet known. This study investigated whether depressive symptomatology is associated with coronary endothelial dysfunction in patients without coronary artery disease (CAD). Methods and results: Incremental acetylcholine (Ach; 20, 50 and 100 μg/min) and nitrate (200 μg/min) were infused into the left coronary ostium of 52 patients (male 30, 51.8 years) with depressive symptoms as indicated by a Beck Depression Inventory (BDI) score of ≥ 10 and a Hamilton Depression Rating Scale (HAM-D17) of ≥ 7 but without overt CAD or any vasoactive medications. Vascular responses to each drug were measured quantitatively at the mid-segments of the left anterior descending artery (LAD) and compared to those of 103 matched control subjects (male 64, 51.3 years) with angiographically normal looking LAD and as estimated by BDI < 10 and HAM-D17 < 7. Patients in the depressive group showed significant vasoconstriction compared with patients in the non-depressive group (p = 0.017, 0.090, 0.004 respectively). However, endothelium-independent vasodilatation to nitrates did not differ significantly between the two groups (p = 0.461). No differences in risk factors were found between the two groups. Conclusions: Depressive mood is associated with coronary endothelial dysfunction in patients without CAD, suggesting a possible mechanism by which depressive mood may act as a cardiovascular risk factor.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalInternational Journal of Cardiology
Volume143
Issue number2
DOIs
Publication statusPublished - 2010 Aug 20

Fingerprint

Coronary Vessels
Depression
Coronary Artery Disease
Nitrates
Arteries
Equipment and Supplies
Vasoconstriction
Vasodilation
Acetylcholine
Endothelium
Coronary Disease
Blood Vessels
Pharmaceutical Preparations

Keywords

  • Acetylcholine
  • Coronary disease
  • Depression
  • Psychiatric status rating scales
  • Risk factors
  • Vascular endothelium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{002cd6dc60d7457897425ff41ff5da86,
title = "Coronary endothelial dysfunction associated with a depressive mood in patients with atypical angina but angiographically normal coronary artery",
abstract = "Background: Depression is a risk factor for the development of coronary heart disease but the relationship between coronary endothelial dysfunction and depression is not yet known. This study investigated whether depressive symptomatology is associated with coronary endothelial dysfunction in patients without coronary artery disease (CAD). Methods and results: Incremental acetylcholine (Ach; 20, 50 and 100 μg/min) and nitrate (200 μg/min) were infused into the left coronary ostium of 52 patients (male 30, 51.8 years) with depressive symptoms as indicated by a Beck Depression Inventory (BDI) score of ≥ 10 and a Hamilton Depression Rating Scale (HAM-D17) of ≥ 7 but without overt CAD or any vasoactive medications. Vascular responses to each drug were measured quantitatively at the mid-segments of the left anterior descending artery (LAD) and compared to those of 103 matched control subjects (male 64, 51.3 years) with angiographically normal looking LAD and as estimated by BDI < 10 and HAM-D17 < 7. Patients in the depressive group showed significant vasoconstriction compared with patients in the non-depressive group (p = 0.017, 0.090, 0.004 respectively). However, endothelium-independent vasodilatation to nitrates did not differ significantly between the two groups (p = 0.461). No differences in risk factors were found between the two groups. Conclusions: Depressive mood is associated with coronary endothelial dysfunction in patients without CAD, suggesting a possible mechanism by which depressive mood may act as a cardiovascular risk factor.",
keywords = "Acetylcholine, Coronary disease, Depression, Psychiatric status rating scales, Risk factors, Vascular endothelium",
author = "Kim, {Ji Hoon} and Kim, {Jin Won} and Young-Hoon Ko and Choi, {Cheol Ung} and Na, {Jin Oh} and Kim, {Eung Ju} and Seung-Woon Rha and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo}",
year = "2010",
month = "8",
day = "20",
doi = "10.1016/j.ijcard.2009.02.004",
language = "English",
volume = "143",
pages = "154--157",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
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TY - JOUR

T1 - Coronary endothelial dysfunction associated with a depressive mood in patients with atypical angina but angiographically normal coronary artery

AU - Kim, Ji Hoon

AU - Kim, Jin Won

AU - Ko, Young-Hoon

AU - Choi, Cheol Ung

AU - Na, Jin Oh

AU - Kim, Eung Ju

AU - Rha, Seung-Woon

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

PY - 2010/8/20

Y1 - 2010/8/20

N2 - Background: Depression is a risk factor for the development of coronary heart disease but the relationship between coronary endothelial dysfunction and depression is not yet known. This study investigated whether depressive symptomatology is associated with coronary endothelial dysfunction in patients without coronary artery disease (CAD). Methods and results: Incremental acetylcholine (Ach; 20, 50 and 100 μg/min) and nitrate (200 μg/min) were infused into the left coronary ostium of 52 patients (male 30, 51.8 years) with depressive symptoms as indicated by a Beck Depression Inventory (BDI) score of ≥ 10 and a Hamilton Depression Rating Scale (HAM-D17) of ≥ 7 but without overt CAD or any vasoactive medications. Vascular responses to each drug were measured quantitatively at the mid-segments of the left anterior descending artery (LAD) and compared to those of 103 matched control subjects (male 64, 51.3 years) with angiographically normal looking LAD and as estimated by BDI < 10 and HAM-D17 < 7. Patients in the depressive group showed significant vasoconstriction compared with patients in the non-depressive group (p = 0.017, 0.090, 0.004 respectively). However, endothelium-independent vasodilatation to nitrates did not differ significantly between the two groups (p = 0.461). No differences in risk factors were found between the two groups. Conclusions: Depressive mood is associated with coronary endothelial dysfunction in patients without CAD, suggesting a possible mechanism by which depressive mood may act as a cardiovascular risk factor.

AB - Background: Depression is a risk factor for the development of coronary heart disease but the relationship between coronary endothelial dysfunction and depression is not yet known. This study investigated whether depressive symptomatology is associated with coronary endothelial dysfunction in patients without coronary artery disease (CAD). Methods and results: Incremental acetylcholine (Ach; 20, 50 and 100 μg/min) and nitrate (200 μg/min) were infused into the left coronary ostium of 52 patients (male 30, 51.8 years) with depressive symptoms as indicated by a Beck Depression Inventory (BDI) score of ≥ 10 and a Hamilton Depression Rating Scale (HAM-D17) of ≥ 7 but without overt CAD or any vasoactive medications. Vascular responses to each drug were measured quantitatively at the mid-segments of the left anterior descending artery (LAD) and compared to those of 103 matched control subjects (male 64, 51.3 years) with angiographically normal looking LAD and as estimated by BDI < 10 and HAM-D17 < 7. Patients in the depressive group showed significant vasoconstriction compared with patients in the non-depressive group (p = 0.017, 0.090, 0.004 respectively). However, endothelium-independent vasodilatation to nitrates did not differ significantly between the two groups (p = 0.461). No differences in risk factors were found between the two groups. Conclusions: Depressive mood is associated with coronary endothelial dysfunction in patients without CAD, suggesting a possible mechanism by which depressive mood may act as a cardiovascular risk factor.

KW - Acetylcholine

KW - Coronary disease

KW - Depression

KW - Psychiatric status rating scales

KW - Risk factors

KW - Vascular endothelium

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U2 - 10.1016/j.ijcard.2009.02.004

DO - 10.1016/j.ijcard.2009.02.004

M3 - Article

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AN - SCOPUS:77956057762

VL - 143

SP - 154

EP - 157

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -