Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Kyung Seop Ahn, Moon Sun Hahm, Eun Jin Park, Hyeong Kyu Lee, Ik Hwan Kim

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalPlanta Medica
Volume64
Issue number5
DOIs
Publication statusPublished - 1998 Jul 13

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ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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