Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breast

Hoiseon Jeong, Youngseok Lee, Jungsuk An, Ok Hee Woo, Kyong Hwa Park, Aeree Kim

Research output: Contribution to journalArticle

Abstract

Backgroud and aim: Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activated transcription factors belonging to the nuclear hormone receptor family. The protein is expressed in various kinds of tumor and has been implicated as a tumor suppressor in most cancers. We aimed to understand the role of PPARγ in breast cancer. Methods: The expression of PPARγ in 288 cases of invasive ductal carcinoma was examined using tissue microarray and immunohistochemistry. Results: PPARγ immunoreactivity was detected in 21.5% of cases and significantly associated with expression of EGFR and ki-67 (P = 0.008; P = 0.046). PPARγ expression was correlated with high histological grade and basal type (P ≤ 0.001; P =0.009).Conclusions: PPARγ expressionis related to poor prognostic factors of breast cancer. It is considered that PPARγ has evident tumor promoting properties in vivo, but receptor-independent effects of PPARγ ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPARγ is required.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalBasic and Applied Pathology
Volume2
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

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Carcinoma, Ductal, Breast
Peroxisome Proliferator-Activated Receptors
Neoplasms
Breast Neoplasms
Ligands
Ductal Carcinoma
Cytoplasmic and Nuclear Receptors
Transcription Factors
Immunohistochemistry

Keywords

  • Breast
  • Carcinoma
  • Ductal
  • Immunohistochemistry
  • Peroxisome proliferating response elememt

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

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title = "Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breast",
abstract = "Backgroud and aim: Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activated transcription factors belonging to the nuclear hormone receptor family. The protein is expressed in various kinds of tumor and has been implicated as a tumor suppressor in most cancers. We aimed to understand the role of PPARγ in breast cancer. Methods: The expression of PPARγ in 288 cases of invasive ductal carcinoma was examined using tissue microarray and immunohistochemistry. Results: PPARγ immunoreactivity was detected in 21.5{\%} of cases and significantly associated with expression of EGFR and ki-67 (P = 0.008; P = 0.046). PPARγ expression was correlated with high histological grade and basal type (P ≤ 0.001; P =0.009).Conclusions: PPARγ expressionis related to poor prognostic factors of breast cancer. It is considered that PPARγ has evident tumor promoting properties in vivo, but receptor-independent effects of PPARγ ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPARγ is required.",
keywords = "Breast, Carcinoma, Ductal, Immunohistochemistry, Peroxisome proliferating response elememt",
author = "Hoiseon Jeong and Youngseok Lee and Jungsuk An and Woo, {Ok Hee} and Park, {Kyong Hwa} and Aeree Kim",
year = "2009",
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doi = "10.1111/j.1755-9294.2009.01053.x",
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TY - JOUR

T1 - Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breast

AU - Jeong, Hoiseon

AU - Lee, Youngseok

AU - An, Jungsuk

AU - Woo, Ok Hee

AU - Park, Kyong Hwa

AU - Kim, Aeree

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Backgroud and aim: Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activated transcription factors belonging to the nuclear hormone receptor family. The protein is expressed in various kinds of tumor and has been implicated as a tumor suppressor in most cancers. We aimed to understand the role of PPARγ in breast cancer. Methods: The expression of PPARγ in 288 cases of invasive ductal carcinoma was examined using tissue microarray and immunohistochemistry. Results: PPARγ immunoreactivity was detected in 21.5% of cases and significantly associated with expression of EGFR and ki-67 (P = 0.008; P = 0.046). PPARγ expression was correlated with high histological grade and basal type (P ≤ 0.001; P =0.009).Conclusions: PPARγ expressionis related to poor prognostic factors of breast cancer. It is considered that PPARγ has evident tumor promoting properties in vivo, but receptor-independent effects of PPARγ ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPARγ is required.

AB - Backgroud and aim: Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activated transcription factors belonging to the nuclear hormone receptor family. The protein is expressed in various kinds of tumor and has been implicated as a tumor suppressor in most cancers. We aimed to understand the role of PPARγ in breast cancer. Methods: The expression of PPARγ in 288 cases of invasive ductal carcinoma was examined using tissue microarray and immunohistochemistry. Results: PPARγ immunoreactivity was detected in 21.5% of cases and significantly associated with expression of EGFR and ki-67 (P = 0.008; P = 0.046). PPARγ expression was correlated with high histological grade and basal type (P ≤ 0.001; P =0.009).Conclusions: PPARγ expressionis related to poor prognostic factors of breast cancer. It is considered that PPARγ has evident tumor promoting properties in vivo, but receptor-independent effects of PPARγ ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPARγ is required.

KW - Breast

KW - Carcinoma

KW - Ductal

KW - Immunohistochemistry

KW - Peroxisome proliferating response elememt

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