Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction

Han Saem Jeong, Soon Jun Hong, Jae Hyoung Park, Jong Ho Kim, Seung Cheol Choi, Chul Min Ahn, Je Sang Kim, Do-Sun Lim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. Methods and Results: Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive Creactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. Conclusions: The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI.

Original languageEnglish
Pages (from-to)1213-1221
Number of pages9
JournalCirculation Journal
Volume76
Issue number5
DOIs
Publication statusPublished - 2012 Apr 30

Fingerprint

Myocardial Infarction
Intercellular Adhesion Molecule-1
ROC Curve
Cell Count
Cytokines
Wounds and Injuries
Proteins

Keywords

  • Acute myocardial infarction
  • Angiogenic cell
  • Coronary flow reserve
  • Endothelial progenitor cell
  • Late-loss

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction. / Jeong, Han Saem; Hong, Soon Jun; Park, Jae Hyoung; Kim, Jong Ho; Choi, Seung Cheol; Ahn, Chul Min; Kim, Je Sang; Lim, Do-Sun.

In: Circulation Journal, Vol. 76, No. 5, 30.04.2012, p. 1213-1221.

Research output: Contribution to journalArticle

Jeong, Han Saem ; Hong, Soon Jun ; Park, Jae Hyoung ; Kim, Jong Ho ; Choi, Seung Cheol ; Ahn, Chul Min ; Kim, Je Sang ; Lim, Do-Sun. / Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction. In: Circulation Journal. 2012 ; Vol. 76, No. 5. pp. 1213-1221.
@article{94362f9aefc44d41965d3bed291a137f,
title = "Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction",
abstract = "Background: The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. Methods and Results: Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive Creactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. Conclusions: The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI.",
keywords = "Acute myocardial infarction, Angiogenic cell, Coronary flow reserve, Endothelial progenitor cell, Late-loss",
author = "Jeong, {Han Saem} and Hong, {Soon Jun} and Park, {Jae Hyoung} and Kim, {Jong Ho} and Choi, {Seung Cheol} and Ahn, {Chul Min} and Kim, {Je Sang} and Do-Sun Lim",
year = "2012",
month = "4",
day = "30",
doi = "10.1253/circj.CJ-11-1485",
language = "English",
volume = "76",
pages = "1213--1221",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "5",

}

TY - JOUR

T1 - Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction

AU - Jeong, Han Saem

AU - Hong, Soon Jun

AU - Park, Jae Hyoung

AU - Kim, Jong Ho

AU - Choi, Seung Cheol

AU - Ahn, Chul Min

AU - Kim, Je Sang

AU - Lim, Do-Sun

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Background: The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. Methods and Results: Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive Creactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. Conclusions: The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI.

AB - Background: The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. Methods and Results: Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive Creactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. Conclusions: The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI.

KW - Acute myocardial infarction

KW - Angiogenic cell

KW - Coronary flow reserve

KW - Endothelial progenitor cell

KW - Late-loss

UR - http://www.scopus.com/inward/record.url?scp=84860196797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860196797&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-11-1485

DO - 10.1253/circj.CJ-11-1485

M3 - Article

VL - 76

SP - 1213

EP - 1221

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 5

ER -